| Title |
Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy
|
|---|---|
| Published in |
Neurotherapeutics, June 2016
|
| DOI | 10.1007/s13311-016-0447-1 |
| Pubmed ID | |
| Authors |
Edith Sturm, Lisa Fellner, Florian Krismer, Werner Poewe, Gregor K. Wenning, Nadia Stefanova |
| Abstract |
Similar to Parkinson disease, multiple system atrophy (MSA) presents neuropathologically with nigral neuronal loss; however, the hallmark intracellular α-synuclein (αSyn) accumulation in MSA affects typically oligodendrocytes to form glial cytoplasmic inclusions. The underlying pathogenic mechanisms remain unclear. As MSA is predominantly sporadic, epigenetic mechanisms may play a role. We tested the effects of the pan-histone deacetylase inhibitor (HDACi) sodium phenylbutyrate in aged mice overexpressing αSyn under the control of the proteolipid protein promoter (PLP-αSyn) designed to model MSA and characterized by αSyn accumulation in oligodendrocytes and nigral neurodegeneration. HDACi improved motor behavior and survival of nigral neurons in PLP-αSyn mice. Furthermore, HDACi reduced the density of oligodendroglial αSyn aggregates, which correlated with the survival of nigral neurons in PLP-αSyn mice. For the first time, we suggest a role of HDACi in the pathogenesis of MSA-like neurodegeneration and support the future development of selective HDACi for MSA therapy. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 20% |
| Canada | 1 | 20% |
| France | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 26% |
| Student > Bachelor | 7 | 17% |
| Researcher | 4 | 10% |
| Student > Postgraduate | 3 | 7% |
| Student > Doctoral Student | 2 | 5% |
| Other | 6 | 14% |
| Unknown | 9 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 17% |
| Medicine and Dentistry | 5 | 12% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Veterinary Science and Veterinary Medicine | 2 | 5% |
| Nursing and Health Professions | 2 | 5% |
| Other | 8 | 19% |
| Unknown | 16 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2017.
All research outputs
#2,655,546
of 25,373,627 outputs
Outputs from Neurotherapeutics
#245
of 1,308 outputs
Outputs of similar age
#45,681
of 354,235 outputs
Outputs of similar age from Neurotherapeutics
#6
of 17 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,308 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,235 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.