| Title |
Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family
|
|---|---|
| Published in |
BMC Molecular and Cell Biology, June 2012
|
| DOI | 10.1186/1472-6807-12-14 |
| Pubmed ID | |
| Authors |
Apirat Chaikuad, Ewa S Pilka, Antonio De Riso, Frank von Delft, Kathryn L Kavanagh, Catherine Vénien-Bryan, Udo Oppermann, Wyatt W Yue |
| Abstract |
Aspartyl aminopeptidase (DNPEP), with specificity towards an acidic amino acid at the N-terminus, is the only mammalian member among the poorly understood M18 peptidases. DNPEP has implicated roles in protein and peptide metabolism, as well as the renin-angiotensin system in blood pressure regulation. Despite previous enzyme and substrate characterization, structural details of DNPEP regarding ligand recognition and catalytic mechanism remain to be delineated. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| India | 1 | 3% |
| Unknown | 32 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 29% |
| Student > Ph. D. Student | 7 | 21% |
| Student > Master | 5 | 15% |
| Professor > Associate Professor | 4 | 12% |
| Student > Doctoral Student | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 3 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 32% |
| Agricultural and Biological Sciences | 11 | 32% |
| Chemistry | 4 | 12% |
| Psychology | 1 | 3% |
| Economics, Econometrics and Finance | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 4 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2020.
All research outputs
#3,621,892
of 25,374,647 outputs
Outputs from BMC Molecular and Cell Biology
#59
of 1,233 outputs
Outputs of similar age
#23,334
of 177,440 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#2
of 21 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.