Title |
A systematic review of studies examining the rate of lung function decline in patients with cystic fibrosis
|
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Published in |
Paediatric Respiratory Reviews, March 2016
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DOI | 10.1016/j.prrv.2016.03.002 |
Pubmed ID | |
Authors |
Sabariah Noor Harun, Claire Wainwright, Kerenaftali Klein, Stefanie Hennig |
Abstract |
A systematic review was performed (i) to describe the reported overall rate of progression of CF lung disease quantified as FEV1%predicted decline with age, (ii) to summarise identified influencing risk factors and (iii) to review methods used to analyse CF lung disease progression data. A search of publications providing FEV1%predicted values over age was conducted in PUBMED and EMBASE. Baseline and rate of FEV1%predicted decline were summarised overall and by identified risk factors. Thirty-nine studies were included and reported variable linear rates of lung function decline in patients with CF. The overall weighted mean FEV1%predicted over age was graphically summarised and showed a nonlinear, time-variant decline of lung function. Compared to their peers, Pseudomonas aeruginosa infection and pancreatic insufficiency were most commonly associated with lower baseline and more rapid FEV1%predicted declines respectively. Considering nonlinear models and drop-out in lung disease progression, analysis is lacking and more studies are warranted. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | <1% |
Unknown | 109 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 16% |
Student > Master | 15 | 14% |
Researcher | 12 | 11% |
Student > Postgraduate | 12 | 11% |
Student > Bachelor | 11 | 10% |
Other | 22 | 20% |
Unknown | 20 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 40 | 36% |
Nursing and Health Professions | 8 | 7% |
Agricultural and Biological Sciences | 8 | 7% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Immunology and Microbiology | 4 | 4% |
Other | 11 | 10% |
Unknown | 32 | 29% |