| Title |
Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease
|
|---|---|
| Published in |
Journal of Neural Transmission, June 2016
|
| DOI | 10.1007/s00702-016-1580-z |
| Pubmed ID | |
| Authors |
Saeed Sadigh-Eteghad, Alireza Majdi, Javad Mahmoudi, Samad E. J. Golzari, Mahnaz Talebi |
| Abstract |
It is increasingly recognized that astrocytes and microglia-associated dysfunction contribute to AD pathology. In addition, glial nicotinic acetylcholine receptors (nAChRs) play a role in AD-related phenomena, such as neuron survival, synaptic plasticity, and memory. From mechanistic point of view, the glial regulation of pro-inflammatory cytokines, as common contributors in AD, is modulated by nAChRs. Astrocytic and microglial nAChRs contribute to Aβ metabolism, including Aβ phagocytosis and degradation as well as Aβ-related oxidative stress and neurotoxicity. These receptors are also involved in neurotransmission and gliotransmission through indirect interaction with N-Methyl-D-aspartate (NMDA) and a-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptors as well as gamma-aminobutyric acid (GABA) and intracellular calcium regulation. In addition, glial nAChRs participate in trophic factors-induced neuroprotection. This review gathers the most recent advances along with the previous data on astrocytic and microglial nAChRs role in AD pathogenesis. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 65 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 26% |
| Student > Bachelor | 10 | 15% |
| Student > Master | 7 | 11% |
| Researcher | 6 | 9% |
| Professor | 4 | 6% |
| Other | 12 | 18% |
| Unknown | 10 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 26 | 39% |
| Biochemistry, Genetics and Molecular Biology | 8 | 12% |
| Agricultural and Biological Sciences | 6 | 9% |
| Unspecified | 4 | 6% |
| Medicine and Dentistry | 3 | 5% |
| Other | 6 | 9% |
| Unknown | 13 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2016.
All research outputs
#13,983,198
of 22,876,619 outputs
Outputs from Journal of Neural Transmission
#1,158
of 1,767 outputs
Outputs of similar age
#185,096
of 339,398 outputs
Outputs of similar age from Journal of Neural Transmission
#23
of 45 outputs
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