| Title |
The Role of Hyaluronan and the Extracellular Matrix in Islet Inflammation and Immune Regulation
|
|---|---|
| Published in |
Current Diabetes Reports, July 2012
|
| DOI | 10.1007/s11892-012-0297-0 |
| Pubmed ID | |
| Authors |
Paul L. Bollyky, Marika Bogdani, Jennifer B. Bollyky, Rebecca L. Hull, Thomas N. Wight |
| Abstract |
Type 1 diabetes (T1D) is a disease that in most individuals results from autoimmune attack of a single tissue type, the pancreatic islet. A fundamental, unanswered question in T1D pathogenesis is how the islet tissue environment influences immune regulation. This crosstalk is likely to be communicated through the extracellular matrix (ECM). Here, we review what is known about the ECM in insulitis and examine how the tissue environment is synchronized with immune regulation. In particular, we focus on the role of hyaluronan (HA) and its interactions with Foxp3+ regulatory T-cells (Treg). We propose that HA is a "keystone molecule" in the inflammatory milieu and that HA, together with its associated binding proteins and receptors, is an appropriate point of entry for investigations into how ECM influences immune regulation in the islet. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Unknown | 70 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 22% |
| Student > Ph. D. Student | 13 | 18% |
| Student > Bachelor | 8 | 11% |
| Student > Master | 8 | 11% |
| Student > Postgraduate | 5 | 7% |
| Other | 9 | 13% |
| Unknown | 13 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 22% |
| Medicine and Dentistry | 14 | 19% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Immunology and Microbiology | 8 | 11% |
| Chemistry | 4 | 6% |
| Other | 7 | 10% |
| Unknown | 15 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2020.
All research outputs
#6,379,761
of 22,671,366 outputs
Outputs from Current Diabetes Reports
#318
of 1,005 outputs
Outputs of similar age
#44,933
of 163,942 outputs
Outputs of similar age from Current Diabetes Reports
#5
of 21 outputs
Altmetric has tracked 22,671,366 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,005 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,942 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.