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Mendeley readers
Attention Score in Context
| Title |
Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21
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|---|---|
| Published in |
Human Genetics, June 2016
|
| DOI | 10.1007/s00439-016-1690-6 |
| Pubmed ID | |
| Authors |
Craig C. Teerlink, Daniel Leongamornlert, Tokhir Dadaev, Alun Thomas, James Farnham, Robert A. Stephenson, Shaun Riska, Shannon K. McDonnell, Daniel J. Schaid, William J. Catalona, S. Lilly Zheng, Kathleen A. Cooney, Anna M. Ray, Kimberly A. Zuhlke, Ethan M. Lange, Graham G. Giles, Melissa C. Southey, Liesel M. Fitzgerald, Antje Rinckleb, Manuel Luedeke, Christiane Maier, Janet L. Stanford, Elaine A. Ostrander, Elina M. Kaikkonen, Csilla Sipeky, Teuvo Tammela, Johanna Schleutker, Kathleen E. Wiley, Sarah D. Isaacs, Patrick C. Walsh, William B. Isaacs, Jianfeng Xu, Geraldine Cancel-Tassin, Olivier Cussenot, Diptasri Mandal, Cecelia Laurie, Cathy Laurie, The PRACTICAL consortium, International Consortium for Prostate Cancer Genetics, Stephen N. Thibodeau, Rosalind A. Eeles, Zsofia Kote-Jarai, Lisa Cannon-Albright |
| Abstract |
Previous genome-wide association studies (GWAS) of prostate cancer risk focused on cases unselected for family history and have reported over 100 significant associations. The International Consortium for Prostate Cancer Genetics (ICPCG) has now performed a GWAS of 2511 (unrelated) familial prostate cancer cases and 1382 unaffected controls from 12 member sites. All samples were genotyped on the Illumina 5M+exome single nucleotide polymorphism (SNP) platform. The GWAS identified a significant evidence for association for SNPs in six regions previously associated with prostate cancer in population-based cohorts, including 3q26.2, 6q25.3, 8q24.21, 10q11.23, 11q13.3, and 17q12. Of note, SNP rs138042437 (p = 1.7e(-8)) at 8q24.21 achieved a large estimated effect size in this cohort (odds ratio = 13.3). 116 previously sampled affected relatives of 62 risk-allele carriers from the GWAS cohort were genotyped for this SNP, identifying 78 additional affected carriers in 62 pedigrees. A test for an excess number of affected carriers among relatives exhibited strong evidence for co-segregation of the variant with disease (p = 8.5e(-11)). The majority (92 %) of risk-allele carriers at rs138042437 had a consistent estimated haplotype spanning approximately 100 kb of 8q24.21 that contained the minor alleles of three rare SNPs (dosage minor allele frequencies <1.7 %), rs183373024 (PRNCR1), previously associated SNP rs188140481, and rs138042437 (CASC19). Strong evidence for co-segregation of a SNP on the haplotype further characterizes the haplotype as a prostate cancer predisposition locus. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| Brazil | 1 | 25% |
| United States | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Unknown | 35 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 22% |
| Researcher | 6 | 17% |
| Professor | 4 | 11% |
| Student > Bachelor | 3 | 8% |
| Student > Master | 3 | 8% |
| Other | 6 | 17% |
| Unknown | 6 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 31% |
| Medicine and Dentistry | 9 | 25% |
| Agricultural and Biological Sciences | 4 | 11% |
| Unspecified | 1 | 3% |
| Economics, Econometrics and Finance | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 7 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2017.
All research outputs
#13,983,198
of 22,876,619 outputs
Outputs from Human Genetics
#2,421
of 2,955 outputs
Outputs of similar age
#185,096
of 339,398 outputs
Outputs of similar age from Human Genetics
#21
of 39 outputs
Altmetric has tracked 22,876,619 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,955 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,398 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.