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Fetal Brain Lesions and TSC

Overview of attention for article published in Brain Pathology, August 2012
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1 Facebook page
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1 Google+ user

Citations

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117 Dimensions

Readers on

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89 Mendeley
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Title
Fetal Brain Lesions and TSC
Published in
Brain Pathology, August 2012
DOI 10.1111/j.1750-3639.2012.00616.x
Pubmed ID
Authors

Avanita S. Prabowo, Jasper J. Anink, Martin Lammens, Mark Nellist, Ans M. W. van den Ouweland, Homa Adle‐Biassette, Harvey B. Sarnat, Laura Flores‐Sarnat, Peter B. Crino, Eleonora Aronica

Abstract

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in either the TSC1 or TSC2 genes and characterized by developmental brain abnormalities. We defined the spectrum of brain abnormalities in fetal TSC brain ranging from 23 to 38 gestational weeks. We hypothesized (i) prenatal activation of the target-of-rapamycin complex 1 (TORC1) signaling pathway; and (ii) activation of inflammatory pathways in fetal brain lesions. Immunocytochemical analysis of cortical tubers, as well as subependymal lesions in all cases confirmed the cell-associated activation of the TORC1 signaling pathway in both the cortical tubers and subependymal lesions (including a congenital subependymal giant cell astrocytoma) with expression of pS6, p4EBP1 and c-myc proteins, as well as of p70 S6 kinase 1. The lesions contained macrophages and T-lymphocytes; giant cells within the lesions expressed inflammatory response markers including major histocompatibility complex class I and II, Toll-like receptors (TLR) 2 and 4 and receptor for advanced glycation end products (RAGE). These observations indicate that brain malformations in TSC are likely a consequence of increased TORC1 activation during embryonic brain development. We also provide evidence supporting the possible immunogenicity of giant cells and the early activation of inflammatory pathways in TSC brain.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 2%
United States 1 1%
Poland 1 1%
Brazil 1 1%
Unknown 84 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 21%
Student > Master 13 15%
Researcher 9 10%
Student > Bachelor 7 8%
Student > Doctoral Student 6 7%
Other 19 21%
Unknown 16 18%
Readers by discipline Count As %
Medicine and Dentistry 24 27%
Neuroscience 16 18%
Agricultural and Biological Sciences 15 17%
Biochemistry, Genetics and Molecular Biology 5 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 7 8%
Unknown 20 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2013.
All research outputs
#16,191,677
of 24,629,540 outputs
Outputs from Brain Pathology
#900
of 1,200 outputs
Outputs of similar age
#111,211
of 175,687 outputs
Outputs of similar age from Brain Pathology
#5
of 9 outputs
Altmetric has tracked 24,629,540 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,200 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,687 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.