| Title |
BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
|
|---|---|
| Published in |
Behavioral and Brain Functions, June 2016
|
| DOI | 10.1186/s12993-016-0101-4 |
| Pubmed ID | |
| Authors |
Galina Y. Zheleznyakova, Hao Cao, Helgi B. Schiöth |
| Abstract |
Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 154 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 18% |
| Researcher | 23 | 15% |
| Student > Master | 22 | 14% |
| Student > Bachelor | 20 | 13% |
| Student > Doctoral Student | 8 | 5% |
| Other | 17 | 11% |
| Unknown | 37 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 15% |
| Medicine and Dentistry | 20 | 13% |
| Psychology | 20 | 13% |
| Neuroscience | 16 | 10% |
| Agricultural and Biological Sciences | 9 | 6% |
| Other | 19 | 12% |
| Unknown | 48 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2021.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Behavioral and Brain Functions
#276
of 417 outputs
Outputs of similar age
#226,915
of 355,624 outputs
Outputs of similar age from Behavioral and Brain Functions
#4
of 7 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 417 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,624 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.