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Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study

Overview of attention for article published in Multiple Sclerosis Journal, July 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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1 policy source
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11 X users

Citations

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108 Dimensions

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152 Mendeley
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Title
Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study
Published in
Multiple Sclerosis Journal, July 2016
DOI 10.1177/1352458516652498
Pubmed ID
Authors

Maria Chiara Buscarinu, Benedetta Cerasoli, Viviana Annibali, Claudia Policano, Luana Lionetto, Matilde Capi, Rosella Mechelli, Silvia Romano, Arianna Fornasiero, Gianluca Mattei, Eleonora Piras, Daniela Francesca Angelini, Luca Battistini, Maurizio Simmaco, Renato Umeton, Marco Salvetti, Giovanni Ristori

Abstract

Alterations of intestinal permeability (IP) may contribute to the pathophysiology of immune-mediated diseases. We investigated the possible association between IP changes and multiple sclerosis (MS). We studied 22 patients with relapsing-remitting multiple sclerosis (RRMS) and 18 age- and sex-matched healthy donors (HDs), including five twin pairs (one concordant, and four discordant for disease). Measurement of lactulose (L) and mannitol (M; two non-metabolized sugars) levels in urine samples, after an oral load, allowed to quantify gut dysfunction. The proportion of participants with increased IP was significantly higher in patients than in HDs (16/22 (73%) versus 5/18 (28%); p = 0.001). Accordingly, the L/M urinary ratio showed significantly higher values in patients than in controls (p = 0.0284). Urinary mannitol concentration was significantly lower in patients than in controls (p = 0.022), suggesting a deficit of absorption from intestinal lumen. Such changes did not appear related to patients' clinical-radiological features. The relatively high proportion of IP changes in RR-MS patients seems to confirm our work hypothesis and warrants more work to confirm the result on a larger sample, and to understand the implications for related immunological disturbances and intestinal microbiota alterations. Our finding may also have relevance for oral treatments, recently introduced in clinical practice.

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X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 1 <1%
Unknown 151 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 14%
Student > Master 21 14%
Researcher 20 13%
Student > Bachelor 16 11%
Other 14 9%
Other 21 14%
Unknown 38 25%
Readers by discipline Count As %
Medicine and Dentistry 27 18%
Neuroscience 20 13%
Agricultural and Biological Sciences 19 13%
Immunology and Microbiology 12 8%
Biochemistry, Genetics and Molecular Biology 12 8%
Other 16 11%
Unknown 46 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2020.
All research outputs
#3,609,612
of 22,876,619 outputs
Outputs from Multiple Sclerosis Journal
#1,203
of 3,455 outputs
Outputs of similar age
#64,904
of 354,309 outputs
Outputs of similar age from Multiple Sclerosis Journal
#100
of 406 outputs
Altmetric has tracked 22,876,619 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,455 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,309 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 406 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.