| Title |
CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy
|
|---|---|
| Published in |
Molecular Pain, July 2012
|
| DOI | 10.1186/1744-8069-8-54 |
| Pubmed ID | |
| Authors |
Andrew D Piekarz, Michael R Due, May Khanna, Bo Wang, Matthew S Ripsch, Ruizhong Wang, Samy O Meroueh, Michael R Vasko, Fletcher A White, Rajesh Khanna |
| Abstract |
The ubiquity of protein-protein interactions in biological signaling offers ample opportunities for therapeutic intervention. We previously identified a peptide, designated CBD3, that suppressed inflammatory and neuropathic behavioral hypersensitivity in rodents by inhibiting the ability of collapsin response mediator protein 2 (CRMP-2) to bind to N-type voltage-activated calcium channels (CaV2.2) [Brittain et al. Nature Medicine 17:822-829 (2011)]. |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 21% |
| Student > Ph. D. Student | 6 | 21% |
| Professor | 3 | 11% |
| Researcher | 3 | 11% |
| Student > Bachelor | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 6 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 29% |
| Medicine and Dentistry | 5 | 18% |
| Chemistry | 3 | 11% |
| Neuroscience | 2 | 7% |
| Psychology | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 7 | 25% |