| Title |
Embryonic Template-Based Generation and Purification of Pluripotent Stem Cell-Derived Cardiomyocytes for Heart Repair
|
|---|---|
| Published in |
Journal of Cardiovascular Translational Research, July 2012
|
| DOI | 10.1007/s12265-012-9391-6 |
| Pubmed ID | |
| Authors |
Pieterjan Dierickx, Pieter A. Doevendans, Niels Geijsen, Linda W. van Laake |
| Abstract |
Cardiovascular disease remains a leading cause of death in Western countries. Many types of cardiovascular diseases are due to a loss of functional cardiomyocytes, which can result in irreversible cardiac failure. Since the adult human heart has limited regenerative potential, cardiac transplantation is still the only effective therapy to address this cardiomyocyte loss. However, drawbacks, such as immune rejection and insufficient donor availability, are limiting this last-resort solution. Recent developments in the stem cell biology field have improved the potential of cardiac regeneration. Improvements in reprogramming strategies of differentiated adult cells into induced pluripotent stem cells, together with increased efficiency of directed differentiation of pluripotent stem cells toward cardiac myocytes, have brought cell-based heart muscle regeneration a few steps closer to the clinic. In this review, we outline the status of research on cardiac regeneration with a focus on directed differentiation of pluripotent stem cells toward the cardiac lineage. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Netherlands | 1 | 2% |
| Italy | 1 | 2% |
| Ireland | 1 | 2% |
| Unknown | 57 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 27% |
| Researcher | 14 | 23% |
| Student > Master | 12 | 19% |
| Student > Doctoral Student | 4 | 6% |
| Student > Bachelor | 3 | 5% |
| Other | 9 | 15% |
| Unknown | 3 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 40% |
| Medicine and Dentistry | 18 | 29% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Engineering | 3 | 5% |
| Business, Management and Accounting | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 4 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2022.
All research outputs
#3,162,978
of 23,056,273 outputs
Outputs from Journal of Cardiovascular Translational Research
#62
of 580 outputs
Outputs of similar age
#21,527
of 164,581 outputs
Outputs of similar age from Journal of Cardiovascular Translational Research
#1
of 11 outputs
Altmetric has tracked 23,056,273 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 580 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,581 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.