Title |
Trauma-Induced Systemic Inflammatory Response versus Exercise-Induced Immunomodulatory Effects
|
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Published in |
Sports Medicine, October 2012
|
DOI | 10.2165/00007256-200636050-00001 |
Pubmed ID | |
Authors |
Elvira Fehrenbach, Marion E. Schneider |
Abstract |
Accidental trauma and heavy endurance exercise, both induce a kind of systemic inflammatory response, also called systemic inflammatory response syndrome (SIRS). Exercise-related SIRS is conditioned by hyperthermia and concomitant heat shock responses, whereas trauma-induced SIRS manifests concomitantly with tissue necrosis and immune activation, secondarily followed by fever. Inflammatory cytokines are common denominators in both trauma and exercise, although there are marked quantitative differences. Different anti-inflammatory cytokines may be involved in the control of inflammation in trauma- and exercise-induced stress. Exercise leads to a balanced equilibrium between inflammatory and anti-inflammatory responses. Intermittent states of rest, as well as anti-oxidant capacity, are lacking or minor in trauma but are high in exercising individuals. Regular training may enhance immune competence, whereas trauma-induced SIRS often paves the way for infectious complications, such as sepsis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 1% |
Unknown | 97 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 15% |
Student > Ph. D. Student | 13 | 13% |
Researcher | 9 | 9% |
Student > Doctoral Student | 8 | 8% |
Professor | 8 | 8% |
Other | 28 | 29% |
Unknown | 17 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Sports and Recreations | 25 | 26% |
Medicine and Dentistry | 17 | 17% |
Agricultural and Biological Sciences | 14 | 14% |
Nursing and Health Professions | 5 | 5% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Other | 12 | 12% |
Unknown | 22 | 22% |