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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8
|
|---|---|
| Published in |
Journal of Biological Chemistry, March 2016
|
| DOI | 10.1074/jbc.m116.721662 |
| Pubmed ID | |
| Authors |
Jennifer R Deuis, Zoltan Dekan, Marco C Inserra, Tzong-Hsien Lee, Marie-Isabel Aguilar, David J Craik, Richard J Lewis, Paul F Alewood, Mehdi Mobli, Christina I Schroeder, Sónia Troeira Henriques, Irina Vetter |
| Abstract |
The μO-conotoxins MrVIA, MrVIB and MfVIA inhibit the voltage-gated sodium channel NaV1.8, a well-described target for the treatment of pain; however, little is known about the residues or structural elements that define this activity. In this study, we determined the three-dimensional structure of MfVIA, examined its membrane-binding properties, performed alanine-scanning mutagenesis and identified residues important for its activity at human NaV1.8. A second round of mutations resulted in [E5K,E8K]MfVIA, a double mutant with greater positive surface charge and greater affinity for lipid membranes compared to MfVIA. This analogue had increased potency at NaV1.8 and was analgesic in the mouse formalin assay. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 26% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 3 | 9% |
| Other | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 8 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 6 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 14% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Medicine and Dentistry | 3 | 9% |
| Agricultural and Biological Sciences | 3 | 9% |
| Other | 3 | 9% |
| Unknown | 11 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2016.
All research outputs
#22,760,732
of 25,377,790 outputs
Outputs from Journal of Biological Chemistry
#82,451
of 85,237 outputs
Outputs of similar age
#272,340
of 315,342 outputs
Outputs of similar age from Journal of Biological Chemistry
#331
of 414 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 85,237 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,342 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 414 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.