| Title |
Comparison of intravascular ultrasound guided versus angiography guided drug eluting stent implantation: a systematic review and meta-analysis
|
|---|---|
| Published in |
BMC Cardiovascular Disorders, November 2015
|
| DOI | 10.1186/s12872-015-0144-8 |
| Pubmed ID | |
| Authors |
Yao-Jun Zhang, Si Pang, Xiao-Yun Chen, Christos V. Bourantas, Dao-Rong Pan, Sheng-Jie Dong, Wen Wu, Xiao-Min Ren, Hao Zhu, Shun-Yi Shi, Javaid Iqbal, Bill D. Gogas, Bo Xu, Shao-Liang Chen |
| Abstract |
Intravascular ultrasound (IVUS) can be a useful tool during drug-eluting stents (DES) implantation as it allows accurate assessment of lesion severity and optimal treatment planning. However, numerous reports have shown that IVUS guided percutaneous coronary intervention is not associated with improved clinical outcomes, especially in non-complex patients and lesions. We searched the literature in Medline, the Cochrane Library, and other internet sources to identify studies that compare clinical outcomes between IVUS-guided and angiography-guided DES implantation. Random-effects model was used to assess treatment effect. Twenty eligible studies with a total of 29,068 patients were included in this meta-analysis. The use of IVUS was associated with significant reductions in major adverse cardiovascular events (MACE, odds ratios [OR] 0.77, 95 % confidence intervals [CI] 0.71-0.83, P < 0.001), death (OR 0.62, 95 % CI 0.54-0.71, p < 0.001), and stent thrombosis (OR 0.59, 95 % CI: 0.47-0.73, P < 0.001). The benefit was also seen in the repeated analysis of matched and randomized studies. In stratified analysis, IVUS guidance appeared to be beneficial not only in patients with complex lesions or acute coronary syndromes (ACS) but also patients with mixed lesions or presentations (MACE: OR 0.69, 95 % CI: 0.60-0.79, p < 0.001, OR 0.81, 95 % CI 0.74-0.90, p < 0.001, respectively). By employing meta-regression analysis, the benefit of IVUS is significantly pronounced in patients with complex lesions or ACS with respect to death (p = 0.048). IVUS guidance was associated with improved clinical outcomes, especially in patients with complex lesions admitted with ACS. Large, randomized clinical trials are warranted to identify populations and lesion characteristics where IVUS guidance would be associated with better outcomes. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 71 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 11 | 15% |
| Student > Master | 8 | 11% |
| Student > Doctoral Student | 7 | 10% |
| Student > Ph. D. Student | 7 | 10% |
| Student > Bachelor | 5 | 7% |
| Other | 9 | 13% |
| Unknown | 24 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 49% |
| Nursing and Health Professions | 2 | 3% |
| Agricultural and Biological Sciences | 1 | 1% |
| Immunology and Microbiology | 1 | 1% |
| Economics, Econometrics and Finance | 1 | 1% |
| Other | 5 | 7% |
| Unknown | 26 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2016.
All research outputs
#4,190,980
of 22,876,619 outputs
Outputs from BMC Cardiovascular Disorders
#180
of 1,618 outputs
Outputs of similar age
#69,236
of 386,583 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#4
of 33 outputs
Altmetric has tracked 22,876,619 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,618 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 386,583 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.