| Title |
HACking the centromere chromatin code: insights from human artificial chromosomes
|
|---|---|
| Published in |
Chromosome Research, July 2012
|
| DOI | 10.1007/s10577-012-9293-0 |
| Pubmed ID | |
| Authors |
Jan H. Bergmann, Nuno M. C. Martins, Vladimir Larionov, Hiroshi Masumoto, William C. Earnshaw |
| Abstract |
The centromere is a specialized chromosomal region that serves as the assembly site of the kinetochore. At the centromere, CENP-A nucleosomes form part of a chromatin landscape termed centrochromatin. This chromatin environment conveys epigenetic marks regulating kinetochore formation. Recent work sheds light on the intricate relationship between centrochromatin state, the CENP-A assembly pathway and the maintenance of centromere function. Here, we review the emerging picture of how chromatin affects mammalian kinetochore formation. We place particular emphasis on data obtained from Human Artificial Chromosome (HAC) biology and the targeted engineering of centrochromatin using synthetic HACs. We discuss implications of these findings, which indicate that a delicate balance of histone modifications and chromatin state dictates both de novo centromere formation and the maintenance of centromere identity in dividing cell populations. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Czechia | 1 | 1% |
| France | 1 | 1% |
| Unknown | 95 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 30% |
| Researcher | 23 | 23% |
| Student > Bachelor | 13 | 13% |
| Student > Master | 11 | 11% |
| Professor > Associate Professor | 6 | 6% |
| Other | 12 | 12% |
| Unknown | 4 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 53% |
| Biochemistry, Genetics and Molecular Biology | 33 | 33% |
| Medicine and Dentistry | 4 | 4% |
| Engineering | 2 | 2% |
| Psychology | 2 | 2% |
| Other | 1 | 1% |
| Unknown | 5 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2015.
All research outputs
#6,913,570
of 22,673,450 outputs
Outputs from Chromosome Research
#126
of 507 outputs
Outputs of similar age
#49,170
of 164,599 outputs
Outputs of similar age from Chromosome Research
#3
of 12 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 507 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,599 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.