Title |
G-CSF and Exenatide Might Be Associated with Increased Long-Term Survival of Allogeneic Pancreatic Islet Grafts
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Published in |
PLOS ONE, June 2016
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DOI | 10.1371/journal.pone.0157245 |
Pubmed ID | |
Authors |
Alessia Zoso, Paolo Serafini, Giacomo Lanzoni, Eduardo Peixoto, Shari Messinger, Alejandro Mantero, Nathalia D. Padilla-Téllez, David A. Baidal, Rodolfo Alejandro, Camillo Ricordi, Luca Inverardi |
Abstract |
Allogeneic human islet transplantation is an effective therapy for the treatment of patients with Type 1 Diabetes (T1D). The low number of islet transplants performed worldwide and the different transplantation protocols used limit the identification of the most effective therapeutic options to improve the efficacy of this approach. We present a retrospective analysis on the data collected from 44 patients with T1D who underwent islet transplantation at our institute between 2000 and 2007. Several variables were included: recipient demographics and immunological characteristics, donor and transplant characteristics, induction protocols, and additional medical treatment received. Immunosuppression was induced with anti-CD25 (Daclizumab), alone or in association with anti-tumor necrosis factor alpha (TNF-α) treatments (Etanercept or Infliximab), or with anti-CD52 (Alemtuzumab) in association with anti-TNF-α treatments (Etanercept or Infliximab). Subsets of patients were treated with Filgrastim for moderate/severe neutropenia and/or Exenatide for post prandial hyperglycemia. The analysis performed indicates a negative association between graft survival (c-peptide level ≥ 0.3 ng/ml) and islet infusion volume, with the caveat that, the progressive reduction of infusion volumes over the years has been paralleled by improved immunosuppressive protocols. A positive association is instead suggested between graft survival and administration of Exenatide and Filgrastim, alone or in combination. This retrospective analysis may be of assistance to further improve long-term outcomes of protocols for transplant of islets and other organs. |
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India | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 12% |
Student > Bachelor | 3 | 12% |
Other | 2 | 8% |
Student > Master | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 16% |
Unknown | 10 | 40% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 32% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Immunology and Microbiology | 1 | 4% |
Other | 1 | 4% |
Unknown | 12 | 48% |