| Title |
Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial
|
|---|---|
| Published in |
World Journal of Pediatrics, June 2016
|
| DOI | 10.1007/s12519-016-0040-z |
| Pubmed ID | |
| Authors |
Faezeh Ghalichi, Jamal Ghaemmaghami, Ayyoub Malek, Alireza Ostadrahimi |
| Abstract |
Genetic and environmental factors are both responsible for the etiology of autism spectrum disorders (ASD). Although epidemiological studies have been conducted to clarify the association between restriction diets and ASD, the conclusion remains unclear. This study was undertaken to investigate the effect of gluten free diet (GFD) on gastrointestinal symptoms and behavioral indices in children with ASD. In this randomized clinical trial, 80 children diagnosed with ASD by the Autism Diagnostic Interview-Revised (ADI-R) were assigned into GFD (n=40) and regular diet (RD) (n=40) groups for 6 weeks. At the beginning and end of the intervention, the ROME Ш questionnaire for evaluating gastrointestinal symptoms and Gilliam Autism Rating Scale 2 questionnaire (GARS-2) for assessing psychometric properties were completed. Of the 80 children, 53.9% had gastrointestinal abnormalities. In the GFD group, the prevalence of gastrointestinal symptoms decreased significantly (P<0.05) after intake of GFD (40.57% vs. 17.10%) but increased insignificantly in the RD group (42.45% vs. 44.05%). GFD intervention resulted in a significant decrease in behavioral disorders (80.03±14.07 vs. 75.82±15.37, P<0.05) but an insignificant increase in the RD group (79.92±15.49 vs. 80.92±16.24). This study suggested that GFD may be effective in controlling gastrointestinal symptoms and ASD behaviors. |
X Demographics
The data shown below were collected from the profiles of 109 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 28 | 26% |
| Spain | 13 | 12% |
| United Kingdom | 9 | 8% |
| Australia | 2 | 2% |
| France | 2 | 2% |
| Canada | 2 | 2% |
| Venezuela, Bolivarian Republic of | 2 | 2% |
| Switzerland | 1 | <1% |
| Andorra | 1 | <1% |
| Other | 5 | 5% |
| Unknown | 44 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 94 | 86% |
| Practitioners (doctors, other healthcare professionals) | 10 | 9% |
| Scientists | 4 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 312 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 310 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 63 | 20% |
| Student > Master | 30 | 10% |
| Researcher | 28 | 9% |
| Student > Doctoral Student | 21 | 7% |
| Student > Ph. D. Student | 15 | 5% |
| Other | 47 | 15% |
| Unknown | 108 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 57 | 18% |
| Nursing and Health Professions | 44 | 14% |
| Agricultural and Biological Sciences | 18 | 6% |
| Neuroscience | 14 | 4% |
| Biochemistry, Genetics and Molecular Biology | 13 | 4% |
| Other | 40 | 13% |
| Unknown | 126 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 132. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2020.
All research outputs
#318,769
of 25,654,806 outputs
Outputs from World Journal of Pediatrics
#5
of 682 outputs
Outputs of similar age
#6,203
of 360,973 outputs
Outputs of similar age from World Journal of Pediatrics
#1
of 15 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 682 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.