| Title |
Interleukin-8 and -10 gene polymorphisms in irritable bowel syndrome
|
|---|---|
| Published in |
Molecular Biology Reports, June 2012
|
| DOI | 10.1007/s11033-012-1745-2 |
| Pubmed ID | |
| Authors |
Mirza Romero-Valdovinos, Areli Gudiño-Ramírez, Jesús Reyes-Gordillo, Williams Arony Martínez-Flores, María Elena Ramírez-Miranda, Pablo Maravilla, Angélica Olivo-Díaz |
| Abstract |
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diagnoses seen by primary care providers and gastroenterologists. Proinflammatory cytokines interleukin (IL)-6 and IL-8 have been found increased in IBS patients. Cytokine gene single nucleotide polymorphisms (SNPs) of IL-8 and IL-10 have not been assessed in Mexican IBS patients. DNA was extracted from peripheral blood leucocytes of 45 IBS unrelated patients and 137 controls. Allele, genotype, and haplotype frequencies were determined by analyzing SNPs of IL-8 and IL-10 genes. IL-8 + 396 G allele (P = 0.02), IL-8 + 396(G/G) and IL-8 + 781(C/T) genotypes (P < 0.001), IL-10 - 1082A allele and IL-10 - 1082(A/A) genotype (P < 0.001) were significantly increased in the IBS group. Haplotypes IL-8 ATCC (P = 0.03) and IL-10 ACC (P < 0.001) were associated with susceptibility to develop IBS. An association of certain polymorphisms of IL-8 and IL-10 in IBS patients compared to controls was demonstrated, suggesting a role of these cytokine SNPs in the pathophysiology of IBS. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 64% |
| Student > Doctoral Student | 2 | 14% |
| Student > Bachelor | 1 | 7% |
| Librarian | 1 | 7% |
| Unknown | 1 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 29% |
| Medicine and Dentistry | 3 | 21% |
| Agricultural and Biological Sciences | 2 | 14% |
| Social Sciences | 2 | 14% |
| Business, Management and Accounting | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 1 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2012.
All research outputs
#12,858,389
of 22,673,450 outputs
Outputs from Molecular Biology Reports
#778
of 2,873 outputs
Outputs of similar age
#87,830
of 164,440 outputs
Outputs of similar age from Molecular Biology Reports
#19
of 47 outputs
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