| Title |
Outcome prognostic factors in inoperable malignant bowel obstruction
|
|---|---|
| Published in |
Supportive Care in Cancer, June 2016
|
| DOI | 10.1007/s00520-016-3299-7 |
| Pubmed ID | |
| Authors |
Margarita Romeo, Maria de los LLanos Gil, José Luís Cuadra Urteaga, Laia Vilà, Sara Ahlal, Alberto Indacochea, Núria Pardo, Joaquim Radua, Albert Font, Albert Tuca |
| Abstract |
Inoperable malignant bowel obstruction (MBO), a severe complication of peritoneal carcinomatosis, has a low desobstruction rate (30-40 %) and end-of-life decision-making is hampered by the lack of known prognostic factors. This study aimed to explore prognostic factors for desobstruction in MBO. All patients with inoperable MBO admitted in our large oncology hospital between 2010 and 2013 were treated following a clinical protocol based on antiemetics, steroids and two antisecretories, octreotide, and hyoscine butylbromide. Two prognostic factor analyses using logistic regressions were performed, one based on data from day 1 of admission and the other on data from day 8. Forty-five patients were included. Frequency of desobstruction was 48.9 %. In the analysis of prognostic factors on day 1, MBO episodes derived from functional physiopathologic mechanisms (vs. mechanic or mixed) were more prone to resolve (p < 0.001 corrected for multiple comparisons). Considering patients alive with persistent obstruction on day 8, a better clinical condition was the variable more associated with desobstruction, but without statistical significance after correction for multiple comparisons. A functional physiopathologic mechanism of MBO development may be an early prognostic factor for desobstruction. A high proportion of desobstruction was observed, suggesting that the combination of antisecretories with different mechanism of action warrants further investigation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 3% |
| Unknown | 37 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 7 | 18% |
| Other | 6 | 16% |
| Student > Master | 5 | 13% |
| Researcher | 5 | 13% |
| Student > Bachelor | 4 | 11% |
| Other | 7 | 18% |
| Unknown | 4 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 53% |
| Nursing and Health Professions | 5 | 13% |
| Engineering | 2 | 5% |
| Agricultural and Biological Sciences | 1 | 3% |
| Environmental Science | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 7 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2016.
All research outputs
#18,463,662
of 22,877,793 outputs
Outputs from Supportive Care in Cancer
#3,591
of 4,593 outputs
Outputs of similar age
#260,405
of 345,199 outputs
Outputs of similar age from Supportive Care in Cancer
#52
of 82 outputs
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