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Variation of BMP3 Contributes to Dog Breed Skull Diversity

Overview of attention for article published in PLoS Genetics, August 2012
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

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4 blogs
twitter
10 X users
facebook
3 Facebook pages

Citations

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151 Dimensions

Readers on

mendeley
233 Mendeley
citeulike
6 CiteULike
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Title
Variation of BMP3 Contributes to Dog Breed Skull Diversity
Published in
PLoS Genetics, August 2012
DOI 10.1371/journal.pgen.1002849
Pubmed ID
Authors

Jeffrey J. Schoenebeck, Sarah A. Hutchinson, Alexandra Byers, Holly C. Beale, Blake Carrington, Daniel L. Faden, Maud Rimbault, Brennan Decker, Jeffrey M. Kidd, Raman Sood, Adam R. Boyko, John W. Fondon, Robert K. Wayne, Carlos D. Bustamante, Brian Ciruna, Elaine A. Ostrander

Abstract

Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our detailed analysis using whole-genome sequencing uncovers a missense mutation in BMP3. Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 233 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 9 4%
France 2 <1%
Portugal 1 <1%
Hungary 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
Spain 1 <1%
Poland 1 <1%
Unknown 216 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 52 22%
Researcher 49 21%
Student > Bachelor 35 15%
Other 16 7%
Student > Master 12 5%
Other 37 16%
Unknown 32 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 100 43%
Biochemistry, Genetics and Molecular Biology 43 18%
Veterinary Science and Veterinary Medicine 18 8%
Medicine and Dentistry 14 6%
Environmental Science 4 2%
Other 19 8%
Unknown 35 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2021.
All research outputs
#1,316,393
of 25,394,764 outputs
Outputs from PLoS Genetics
#979
of 8,960 outputs
Outputs of similar age
#7,415
of 179,338 outputs
Outputs of similar age from PLoS Genetics
#12
of 176 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,960 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,338 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 176 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.