| Title |
Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing
|
|---|---|
| Published in |
European Journal of Applied Physiology, June 2016
|
| DOI | 10.1007/s00421-016-3411-1 |
| Pubmed ID | |
| Authors |
Philipp Baumert, Mark J. Lake, Claire E. Stewart, Barry Drust, Robert M. Erskine |
| Abstract |
Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can result in ultrastructural muscle disruption, impaired excitation-contraction coupling, inflammation and muscle protein degradation. This process is associated with delayed onset muscle soreness and is referred to as exercise-induced muscle damage. Although a certain amount of muscle damage may be necessary for adaptation to occur, excessive damage or inadequate recovery from exercise-induced muscle damage can increase injury risk, particularly in older individuals, who experience more damage and require longer to recover from muscle damaging exercise than younger adults. Furthermore, it is apparent that inter-individual variation exists in the response to exercise-induced muscle damage, and there is evidence that genetic variability may play a key role. Although this area of research is in its infancy, certain gene variations, or polymorphisms have been associated with exercise-induced muscle damage (i.e. individuals with certain genotypes experience greater muscle damage, and require longer recovery, following strenuous exercise). These polymorphisms include ACTN3 (R577X, rs1815739), TNF (-308 G>A, rs1800629), IL6 (-174 G>C, rs1800795), and IGF2 (ApaI, 17200 G>A, rs680). Knowing how someone is likely to respond to a particular type of exercise could help coaches/practitioners individualise the exercise training of their athletes/patients, thus maximising recovery and adaptation, while reducing overload-associated injury risk. The purpose of this review is to provide a critical analysis of the literature concerning gene polymorphisms associated with exercise-induced muscle damage, both in young and older individuals, and to highlight the potential mechanisms underpinning these associations, thus providing a better understanding of exercise-induced muscle damage. |
X Demographics
The data shown below were collected from the profiles of 78 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 31 | 40% |
| United States | 8 | 10% |
| Australia | 4 | 5% |
| Chile | 2 | 3% |
| Ireland | 2 | 3% |
| Brazil | 1 | 1% |
| South Africa | 1 | 1% |
| Austria | 1 | 1% |
| Ecuador | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 25 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 36 | 46% |
| Scientists | 35 | 45% |
| Practitioners (doctors, other healthcare professionals) | 6 | 8% |
| Unknown | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 470 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 467 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 76 | 16% |
| Student > Bachelor | 59 | 13% |
| Student > Ph. D. Student | 53 | 11% |
| Researcher | 43 | 9% |
| Other | 24 | 5% |
| Other | 87 | 19% |
| Unknown | 128 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 120 | 26% |
| Biochemistry, Genetics and Molecular Biology | 51 | 11% |
| Medicine and Dentistry | 49 | 10% |
| Agricultural and Biological Sciences | 35 | 7% |
| Nursing and Health Professions | 33 | 7% |
| Other | 37 | 8% |
| Unknown | 145 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 195. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2022.
All research outputs
#205,020
of 25,582,611 outputs
Outputs from European Journal of Applied Physiology
#45
of 4,372 outputs
Outputs of similar age
#3,975
of 369,057 outputs
Outputs of similar age from European Journal of Applied Physiology
#3
of 50 outputs
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So far Altmetric has tracked 4,372 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.7. This one has done particularly well, scoring higher than 98% of its peers.
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