| Title |
Downhill running in rats: influence on neutrophils, macrophages, and MyoD+ cells in skeletal muscle
|
|---|---|
| Published in |
European Journal of Applied Physiology, September 2003
|
| DOI | 10.1007/s00421-003-0909-0 |
| Pubmed ID | |
| Authors |
Susan K. Tsivitse, Thomas J. McLoughlin, Jennifer M. Peterson, Eleni Mylona, Stephen J. McGregor, Francis X. Pizza |
| Abstract |
The accumulation of neutrophils and macrophages, as well as the activation of satellite cells, are early events following skeletal muscle injury. We examined the temporal relationship between changes in neutrophils, macrophages, and MyoD protein, a marker of satellite cell activation, after injurious exercise. Male rats ( n=47) performed an intermittent downhill (-16% grade) running (17 m/min) protocol and the solei were obtained at 0, 2, 6, 24, 48, or 72 h post-exercise. Neutrophils, macrophages (ED1 and ED2), and MyoD+ cells were determined in muscle cross sections using immunohistochemistry. Downhill running increased ( P<or=0.05) the percentage of injured fibers and elevated blood creatine kinase activity. Neutrophils were elevated 18-fold relative to controls at 24 h post-exercise. ED1 macrophages were elevated four- and twofold at 24 and 48 h post-exercise, respectively. Neither ED2 macrophages nor MyoD+ cells were elevated post-exercise. These observations may indicate that elevations in neutrophils and ED1 macrophages after injurious exercise are not temporally associated with an increase in satellite cell activation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 6% |
| Australia | 2 | 4% |
| Spain | 1 | 2% |
| France | 1 | 2% |
| Unknown | 40 | 85% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 21% |
| Student > Master | 9 | 19% |
| Researcher | 5 | 11% |
| Student > Bachelor | 4 | 9% |
| Professor | 4 | 9% |
| Other | 7 | 15% |
| Unknown | 8 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 32% |
| Sports and Recreations | 9 | 19% |
| Medicine and Dentistry | 3 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Engineering | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 12 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2016.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from European Journal of Applied Physiology
#4,069
of 4,345 outputs
Outputs of similar age
#52,596
of 54,007 outputs
Outputs of similar age from European Journal of Applied Physiology
#23
of 24 outputs
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