Title |
Rapid One-Step Selection Method for Generating Nucleic Acid Aptamers: Development of a DNA Aptamer against α-Bungarotoxin
|
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Published in |
PLOS ONE, July 2012
|
DOI | 10.1371/journal.pone.0041702 |
Pubmed ID | |
Authors |
Lasse H. Lauridsen, Hadi A. Shamaileh, Stacey L. Edwards, Elena Taran, Rakesh N. Veedu |
Abstract |
Nucleic acids based therapeutic approaches have gained significant interest in recent years towards the development of therapeutics against many diseases. Recently, research on aptamers led to the marketing of Macugen®, an inhibitor of vascular endothelial growth factor (VEGF) for the treatment of age related macular degeneration (AMD). Aptamer technology may prove useful as a therapeutic alternative against an array of human maladies. Considering the increased interest in aptamer technology globally that rival antibody mediated therapeutic approaches, a simplified selection, possibly in one-step, technique is required for developing aptamers in limited time period. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
Brazil | 1 | <1% |
Belgium | 1 | <1% |
China | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 131 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 44 | 32% |
Student > Ph. D. Student | 31 | 23% |
Student > Master | 14 | 10% |
Student > Bachelor | 11 | 8% |
Other | 5 | 4% |
Other | 13 | 9% |
Unknown | 19 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 41 | 30% |
Biochemistry, Genetics and Molecular Biology | 33 | 24% |
Chemistry | 14 | 10% |
Immunology and Microbiology | 7 | 5% |
Engineering | 7 | 5% |
Other | 13 | 9% |
Unknown | 22 | 16% |