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A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies

Overview of attention for article published in Oncotarget, May 2015
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Title
A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies
Published in
Oncotarget, May 2015
DOI 10.18632/oncotarget.4096
Pubmed ID
Authors

Alessandra Drusco, Arianna Bottoni, Alessandro Laganà, Mario Acunzo, Matteo Fassan, Luciano Cascione, Anna Antenucci, Prasanthi Kumchala, Caterina Vicentini, Marina P. Gardiman, Hansjuerg Alder, Mariantonia A. Carosi, Mario Ammirati, Stefano Gherardi, Marilena Luscrì, Carmine Carapella, Nicola Zanesi, Carlo M. Croce

Abstract

Central Nervous System malignancies often require stereotactic biopsy or biopsy for differential diagnosis, and for tumor staging and grading. Furthermore, stereotactic biopsy can be non-diagnostic or underestimate grading. Hence, there is a compelling need of new diagnostic biomarkers to avoid such invasive procedures. Several biological markers have been proposed, but they can only identify specific prognostic subtype of Central Nervous System tumors, and none of them has found a standardized clinical application.The aim of the study was to identify a Cerebro-Spinal Fluid microRNA signature that could differentiate among Central Nervous System malignancies.CSF total RNA of 34 neoplastic and of 14 non-diseased patients was processed by NanoString. Comparison among groups (Normal, Benign, Glioblastoma, Medulloblastoma, Metastasis and Lymphoma) lead to the identification of a microRNA profile that was further confirmed by RT-PCR and in situ hybridization.Hsa-miR-451, -711, 935, -223 and -125b were significantly differentially expressed among the above mentioned groups, allowing us to draw an hypothetical diagnostic chart for Central Nervous System malignancies.This is the first study to employ the NanoString technique for Cerebro-Spinal Fluid microRNA profiling. In this article, we demonstrated that Cerebro-Spinal Fluid microRNA profiling mirrors Central Nervous System physiologic or pathologic conditions. Although more cases need to be tested, we identified a diagnostic Cerebro-Spinal Fluid microRNA signature with good perspectives for future diagnostic clinical applications.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Unknown 74 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 16%
Researcher 10 13%
Student > Master 8 11%
Student > Bachelor 7 9%
Student > Doctoral Student 6 8%
Other 13 17%
Unknown 19 25%
Readers by discipline Count As %
Medicine and Dentistry 16 21%
Neuroscience 10 13%
Biochemistry, Genetics and Molecular Biology 9 12%
Agricultural and Biological Sciences 8 11%
Veterinary Science and Veterinary Medicine 2 3%
Other 4 5%
Unknown 26 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2016.
All research outputs
#20,333,181
of 22,877,793 outputs
Outputs from Oncotarget
#10,572
of 14,327 outputs
Outputs of similar age
#222,908
of 266,665 outputs
Outputs of similar age from Oncotarget
#381
of 551 outputs
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