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Attention Score in Context
| Title |
Developing oxygen-enhanced magnetic resonance imaging as a prognostic biomarker of radiation response
|
|---|---|
| Published in |
Cancer Letters, June 2016
|
| DOI | 10.1016/j.canlet.2016.06.003 |
| Pubmed ID | |
| Authors |
Derek A. White, Zhang Zhang, Li Li, Jeni Gerberich, Strahinja Stojadinovic, Peter Peschke, Ralph P. Mason |
| Abstract |
Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI) techniques were evaluated as potential non-invasive predictive biomarkers of radiation response. Semi quantitative blood-oxygen level dependent (BOLD) and tissue oxygen level dependent (TOLD) contrast, and quantitative responses of relaxation rates (ΔR1 and ΔR2*) to an oxygen breathing challenge during hypofractionated radiotherapy were applied. OE-MRI was performed on subcutaneous Dunning R3327-AT1 rat prostate tumors (n=25) at 4.7 T prior to each irradiation (2F × 15 Gy) to the gross tumor volume. Response to radiation, while inhaling air or oxygen, was assessed by tumor growth delay measured up to four times the initial irradiated tumor volume (VQT). Radiation-induced hypoxia changes were confirmed using a double hypoxia marker assay. Inhaling oxygen during hypofractionated radiotherapy significantly improved radiation response. A correlation was observed between the difference in the 2nd and 1st ΔR1 (ΔΔR1) and VQT for air breathing rats. The TOLD response before the 2nd fraction showed a moderate correlation with VQT for oxygen breathing rats. The correlations indicate useful prognostic factors to predict tumor response to hypofractionation and could readily be applied for patient stratification and personalized radiotherapy treatment planning. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Netherlands | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 74 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 16% |
| Student > Ph. D. Student | 10 | 14% |
| Student > Bachelor | 9 | 12% |
| Other | 8 | 11% |
| Student > Master | 8 | 11% |
| Other | 18 | 24% |
| Unknown | 9 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 27% |
| Physics and Astronomy | 14 | 19% |
| Agricultural and Biological Sciences | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Engineering | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 17 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2016.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from Cancer Letters
#4,371
of 6,177 outputs
Outputs of similar age
#225,745
of 354,235 outputs
Outputs of similar age from Cancer Letters
#42
of 70 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,177 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.