| Title |
Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States
|
|---|---|
| Published in |
European Journal of Epidemiology, June 2016
|
| DOI | 10.1007/s10654-016-0169-z |
| Pubmed ID | |
| Authors |
Melina Arnold, Heinz Freisling, Rachael Stolzenberg-Solomon, Frank Kee, Mark George O’Doherty, José Manuel Ordóñez-Mena, Tom Wilsgaard, Anne Maria May, Hendrik Bas Bueno-de-Mesquita, Anne Tjønneland, Philippos Orfanos, Antonia Trichopoulou, Paolo Boffetta, Freddie Bray, Mazda Jenab, Isabelle Soerjomataram, on behalf of the CHANCES consortium |
| Abstract |
Recent studies have shown that cancer risk related to overweight and obesity is mediated by time and might be better approximated by using life years lived with excess weight. In this study we aimed to assess the impact of overweight duration and intensity in older adults on the risk of developing different forms of cancer. Study participants from seven European and one US cohort study with two or more weight assessments during follow-up were included (n = 329,576). Trajectories of body mass index (BMI) across ages were estimated using a quadratic growth model; overweight duration (BMI ≥ 25) and cumulative weighted overweight years were calculated. In multivariate Cox models and random effects analyses, a longer duration of overweight was significantly associated with the incidence of obesity-related cancer [overall hazard ratio (HR) per 10-year increment: 1.36; 95 % CI 1.12-1.60], but also increased the risk of postmenopausal breast and colorectal cancer. Additionally accounting for the degree of overweight further increased the risk of obesity-related cancer. Risks associated with a longer overweight duration were higher in men than in women and were attenuated by smoking. For postmenopausal breast cancer, increased risks were confined to women who never used hormone therapy. Overall, 8.4 % of all obesity-related cancers could be attributed to overweight at any age. These findings provide further insights into the role of overweight duration in the etiology of cancer and indicate that weight control is relevant at all ages. This knowledge is vital for the development of effective and targeted cancer prevention strategies. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 25% |
| Australia | 1 | 8% |
| United Kingdom | 1 | 8% |
| Ireland | 1 | 8% |
| Slovenia | 1 | 8% |
| Unknown | 5 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 75% |
| Practitioners (doctors, other healthcare professionals) | 2 | 17% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 111 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 19% |
| Student > Master | 14 | 13% |
| Student > Bachelor | 9 | 8% |
| Other | 7 | 6% |
| Professor | 7 | 6% |
| Other | 22 | 20% |
| Unknown | 31 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 36% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Agricultural and Biological Sciences | 4 | 4% |
| Nursing and Health Professions | 4 | 4% |
| Social Sciences | 4 | 4% |
| Other | 16 | 14% |
| Unknown | 37 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2022.
All research outputs
#885,623
of 23,202,641 outputs
Outputs from European Journal of Epidemiology
#141
of 1,649 outputs
Outputs of similar age
#18,506
of 353,837 outputs
Outputs of similar age from European Journal of Epidemiology
#4
of 26 outputs
Altmetric has tracked 23,202,641 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,649 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.4. This one has done particularly well, scoring higher than 91% of its peers.
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We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.