Title |
Extent of altered white matter in unilateral and bilateral periventricular white matter lesions in children with unilateral cerebral palsy
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Published in |
Analysis and Intervention in Developmental Disabilities, August 2016
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DOI | 10.1016/j.ridd.2016.04.007 |
Pubmed ID | |
Authors |
Simon M. Scheck, Jurgen Fripp, Lee Reid, Kerstin Pannek, Simona Fiori, Roslyn N. Boyd, Stephen E. Rose |
Abstract |
To investigate the extent of white matter damage in children with unilateral cerebral palsy (UCP) caused by periventricular white matter lesions comparing between unilateral and bilateral lesions; and to investigate a relationship between white matter microstructure and hand function. Diffusion MRI images from 46 children with UCP and 18 children with typical development (CTD) were included. Subjects were grouped by side of hemiparesis and unilateral or bilateral lesions. A voxel-wise white matter analysis was performed to identify regions where fractional anisotropy (FA) was significantly different between UCP groups and CTD; and where FA correlated with either dominant or impaired hand function (using Jebsen Taylor Hand Function Test). Children with unilateral lesions had reduced FA in the corticospinal tract of the affected hemisphere. Children with bilateral lesions had widespread reduced FA extending into all lobes. In children with left hemiparesis, impaired hand function correlated with FA in the contralateral corticospinal tract. Dominant hand function correlated with FA in the posterior thalamic radiations as well as multiple other regions in both left and right hemiparesis groups. Periventricular white matter lesions consist of focal and diffuse components. Focal lesions may cause direct motor fibre insult resulting in motor impairment. Diffuse white matter injury is heterogeneous, and may contribute to more global dysfunction. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 28% |
Student > Master | 7 | 13% |
Researcher | 5 | 9% |
Student > Doctoral Student | 3 | 6% |
Other | 2 | 4% |
Other | 5 | 9% |
Unknown | 16 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 23% |
Nursing and Health Professions | 4 | 8% |
Agricultural and Biological Sciences | 4 | 8% |
Psychology | 4 | 8% |
Neuroscience | 3 | 6% |
Other | 3 | 6% |
Unknown | 23 | 43% |