Title |
Prolonged Neuropsychiatric Symptoms in a Military Service Member Exposed to Mefloquine
|
---|---|
Published in |
Drug Safety - Case Reports, June 2016
|
DOI | 10.1007/s40800-016-0030-z |
Pubmed ID | |
Authors |
Jeffrey Livezey, Thomas Oliver, Louis Cantilena |
Abstract |
A 32-year-old male developed neuropsychiatric symptoms 2 weeks after starting mefloquine 250 mg/week for malaria prophylaxis. He continued to take the medication for the next 4 months. Initial symptoms included vivid dreams and anxiety, as well as balance problems. These symptoms persisted and progressed over the next 4 years to include vertigo, emotional lability, and poor short-term memory, which have greatly affected his personal and professional life. An extensive evaluation revealed objective evidence supporting a central vestibulopathy. These symptoms have been unresponsive to pharmacologic therapy and psychotherapy. A Naranjo assessment score of 6 was obtained for his initial symptoms, indicating a probable adverse drug reaction to mefloquine given the relationship between the clinical picture and drug exposure. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 17% |
Australia | 4 | 9% |
United Kingdom | 4 | 9% |
Canada | 3 | 6% |
New Zealand | 1 | 2% |
Comoros | 1 | 2% |
Italy | 1 | 2% |
Unknown | 25 | 53% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 40 | 85% |
Practitioners (doctors, other healthcare professionals) | 3 | 6% |
Science communicators (journalists, bloggers, editors) | 2 | 4% |
Scientists | 1 | 2% |
Unknown | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 16% |
Student > Ph. D. Student | 3 | 12% |
Researcher | 3 | 12% |
Student > Master | 3 | 12% |
Lecturer | 1 | 4% |
Other | 4 | 16% |
Unknown | 7 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 16% |
Agricultural and Biological Sciences | 3 | 12% |
Psychology | 3 | 12% |
Nursing and Health Professions | 2 | 8% |
Computer Science | 2 | 8% |
Other | 5 | 20% |
Unknown | 6 | 24% |