| Title |
Autism spectrum disorder prevalence and associations with air concentrations of lead, mercury, and arsenic
|
|---|---|
| Published in |
Environmental Monitoring and Assessment, June 2016
|
| DOI | 10.1007/s10661-016-5405-1 |
| Pubmed ID | |
| Authors |
Aisha S. Dickerson, Mohammad H. Rahbar, Amanda V. Bakian, Deborah A. Bilder, Rebecca A. Harrington, Sydney Pettygrove, Russell S. Kirby, Maureen S. Durkin, Inkyu Han, Lemuel A. Moyé, Deborah A. Pearson, Martha Slay Wingate, Walter M. Zahorodny |
| Abstract |
Lead, mercury, and arsenic are neurotoxicants with known effects on neurodevelopment. Autism spectrum disorder (ASD) is a neurodevelopmental disorder apparent by early childhood. Using data on 4486 children with ASD residing in 2489 census tracts in five sites of the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring (ADDM) Network, we used multi-level negative binomial models to investigate if ambient lead, mercury, and arsenic concentrations, as measured by the US Environmental Protection Agency National-Scale Air Toxics Assessment (EPA-NATA), were associated with ASD prevalence. In unadjusted analyses, ambient metal concentrations were negatively associated with ASD prevalence. After adjusting for confounding factors, tracts with air concentrations of lead in the highest quartile had significantly higher ASD prevalence than tracts with lead concentrations in the lowest quartile (prevalence ratio (PR) = 1.36; 95 '% CI: 1.18, 1.57). In addition, tracts with mercury concentrations above the 75th percentile (>1.7 ng/m(3)) and arsenic concentrations below the 75th percentile (≤0.13 ng/m(3)) had a significantly higher ASD prevalence (adjusted RR = 1.20; 95 % CI: 1.03, 1.40) compared to tracts with arsenic, lead, and mercury concentrations below the 75th percentile. Our results suggest a possible association between ambient lead concentrations and ASD prevalence and demonstrate that exposure to multiple metals may have synergistic effects on ASD prevalence. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 17% |
| Australia | 1 | 8% |
| Spain | 1 | 8% |
| Argentina | 1 | 8% |
| Unknown | 7 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 92% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 125 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 16% |
| Student > Master | 19 | 15% |
| Student > Bachelor | 11 | 9% |
| Student > Ph. D. Student | 9 | 7% |
| Student > Doctoral Student | 8 | 6% |
| Other | 25 | 20% |
| Unknown | 33 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 21% |
| Psychology | 12 | 10% |
| Nursing and Health Professions | 11 | 9% |
| Social Sciences | 9 | 7% |
| Agricultural and Biological Sciences | 7 | 6% |
| Other | 23 | 18% |
| Unknown | 37 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2017.
All research outputs
#2,118,527
of 25,654,806 outputs
Outputs from Environmental Monitoring and Assessment
#84
of 3,092 outputs
Outputs of similar age
#37,602
of 369,298 outputs
Outputs of similar age from Environmental Monitoring and Assessment
#3
of 46 outputs
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We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.