| Title |
Subtle deficits of cognitive theory of mind in unaffected first-degree relatives of schizophrenia patients
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, September 2011
|
| DOI | 10.1007/s00406-011-0250-2 |
| Pubmed ID | |
| Authors |
Christiane Montag, Kathrin Neuhaus, Anja Lehmann, Katja Krüger, Isabel Dziobek, Hauke R. Heekeren, Andreas Heinz, Jürgen Gallinat |
| Abstract |
Alterations of theory of mind (ToM) and empathy were implicated in the formation of psychotic experiences, and deficits in psychosocial functioning of schizophrenia patients. Inspired by concepts of neurocognitive endophenotypes, the existence of a distinct, potentially neurobiologically based social-cognitive vulnerability marker for schizophrenia is a matter of ongoing debate. The fact that previous research on social-cognitive deficits in individuals at risk yielded contradictory results may partly be due to an insufficient differentiation between qualitative aspects of ToM. Thirty-four unaffected first-degree relatives of schizophrenia patients (21 parents, 8 siblings, 5 children; f/m: 30/4; mean age: 48.1 ± 12.7 years) and 34 controls subjects (f/m: 25/9; mean age: 45.9 ± 10.9 years) completed the 'Movie for the Assessment of Social Cognition'-a video-based ToM test-and an empathy questionnaire (Interpersonal Reactivity Index, IRI). Outcome parameters comprised (1) 'cognitive' versus 'emotional' ToM, (2) error counts representing 'undermentalizing' versus 'overmentalizing', (3) empathic abilities and (4) non-social neurocognition. MANCOVA showed impairments in cognitive but not emotional ToM in the relatives' group, when age, gender and neurocognition were controlled for. Relatives showed elevated error counts for 'undermentalizing' but not for 'overmentalizing'. No alterations were detected in self-rated dimensions of empathy. Of all measures of ToM and empathy, only the IRI subscale 'fantasy' was associated with measures of psychotic risk, i.e. a history of subclinical delusional ideation. The present study confirmed subtle deficits in cognitive, but not emotional ToM in first-degree relatives of schizophrenia patients, which were not explained by global cognitive deficits. Findings corroborate the assumption of distinct social-cognitive abilities as an intermediate phenotype for schizophrenia. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 1% |
| United States | 2 | 1% |
| Germany | 2 | 1% |
| Unknown | 147 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 24% |
| Student > Master | 22 | 14% |
| Student > Doctoral Student | 18 | 12% |
| Student > Bachelor | 12 | 8% |
| Researcher | 10 | 7% |
| Other | 23 | 15% |
| Unknown | 32 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 79 | 52% |
| Medicine and Dentistry | 12 | 8% |
| Neuroscience | 11 | 7% |
| Chemistry | 2 | 1% |
| Business, Management and Accounting | 2 | 1% |
| Other | 9 | 6% |
| Unknown | 38 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2012.
All research outputs
#2,226,437
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#116
of 1,243 outputs
Outputs of similar age
#10,915
of 127,117 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#2
of 17 outputs
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So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done particularly well, scoring higher than 99% of its peers.
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