↓ Skip to main content

O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability

Overview of attention for article published in Cell Metabolism (Science Direct), August 2012
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
239 Dimensions

Readers on

mendeley
197 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability
Published in
Cell Metabolism (Science Direct), August 2012
DOI 10.1016/j.cmet.2012.07.006
Pubmed ID
Authors

Hai-Bin Ruan, Xuemei Han, Min-Dian Li, Jay Prakash Singh, Kevin Qian, Sascha Azarhoush, Lin Zhao, Anton M. Bennett, Varman T. Samuel, Jing Wu, John R. Yates, Xiaoyong Yang

Abstract

A major cause of hyperglycemia in diabetic patients is inappropriate hepatic gluconeogenesis. PGC-1α is a master regulator of gluconeogenesis, and its activity is controlled by various posttranslational modifications. A small portion of glucose metabolizes through the hexosamine biosynthetic pathway, which leads to O-linked β-N-acetylglucosamine (O-GlcNAc) modification of cytoplasmic and nuclear proteins. Using a proteomic approach, we identified a broad variety of proteins associated with O-GlcNAc transferase (OGT), among which host cell factor C1 (HCF-1) is highly abundant. HCF-1 recruits OGT to O-GlcNAcylate PGC-1α, and O-GlcNAcylation facilitates the binding of the deubiquitinase BAP1, thus protecting PGC-1α from degradation and promoting gluconeogenesis. Glucose availability modulates gluconeogenesis through the regulation of PGC-1α O-GlcNAcylation and stability by the OGT/HCF-1 complex. Hepatic knockdown of OGT and HCF-1 improves glucose homeostasis in diabetic mice. These findings define the OGT/HCF-1 complex as a glucose sensor and key regulator of gluconeogenesis, shedding light on new strategies for treating diabetes.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 1%
Portugal 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 191 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 24%
Researcher 37 19%
Student > Master 22 11%
Student > Bachelor 10 5%
Professor > Associate Professor 9 5%
Other 29 15%
Unknown 42 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 57 29%
Biochemistry, Genetics and Molecular Biology 50 25%
Medicine and Dentistry 14 7%
Chemistry 14 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 2%
Other 7 4%
Unknown 51 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2012.
All research outputs
#20,674,485
of 25,394,764 outputs
Outputs from Cell Metabolism (Science Direct)
#3,020
of 3,170 outputs
Outputs of similar age
#140,100
of 179,231 outputs
Outputs of similar age from Cell Metabolism (Science Direct)
#35
of 38 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,170 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 74.0. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,231 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.