| Title |
Ambient Mass Spectrometry Imaging: A Comparison of Desorption Ionization by Sonic Spray and Electrospray
|
|---|---|
| Published in |
Journal of the American Society for Mass Spectrometry, August 2012
|
| DOI | 10.1007/s13361-012-0452-5 |
| Pubmed ID | |
| Authors |
Christian Janfelt, Asger W. Nørgaard |
| Abstract |
Easy ambient sonic spray ionization (EASI) and desorption electrospray ionization (DESI) were used for imaging of a number of samples, including sections of rat brain and imprints of plant material on porous Teflon. A novel approach termed Displaced Dual-mode Imaging was utilized for the direct comparison of the two methods: Images were recorded with the individual rows alternating between EASI and DESI, yielding a separate image for each technique recorded under perfectly similar conditions on the same sample. EASI works reliably for imaging of all samples, but the choice of spray solvent and flow rate is more critical in tissue imaging with EASI than with DESI. The overall sensitivity of EASI is, in general, slightly lower than that of DESI, and the representation of the dynamic range is different in images of the two techniques for some samples. However, for abundant compounds, EASI works well, resulting in images of similar quality as DESI. EASI can thus be used in imaging experiments where the application of high voltage is impractical or undesirable. The present study is in its nature also a comparison of the characteristics of the two techniques, showing results also applicable for non-imaging work, with regards to sensitivity and experimental conditions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Unknown | 45 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 21% |
| Researcher | 9 | 19% |
| Student > Master | 6 | 13% |
| Student > Bachelor | 4 | 9% |
| Professor | 4 | 9% |
| Other | 9 | 19% |
| Unknown | 5 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 27 | 57% |
| Agricultural and Biological Sciences | 3 | 6% |
| Engineering | 3 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Computer Science | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 8 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2012.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Journal of the American Society for Mass Spectrometry
#3,428
of 3,834 outputs
Outputs of similar age
#167,096
of 184,943 outputs
Outputs of similar age from Journal of the American Society for Mass Spectrometry
#38
of 61 outputs
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