| Title |
Satisfaction, Adherence and Health-Related Quality of Life with Transdermal Buprenorphine Compared with Oral Opioid Medications in the Usual Care of Osteoarthritis Pain
|
|---|---|
| Published in |
The Patient - Patient-Centered Outcomes Research, June 2016
|
| DOI | 10.1007/s40271-016-0181-0 |
| Pubmed ID | |
| Authors |
Philip G. Conaghan, Michael Serpell, Paula McSkimming, Rod Junor, Sara Dickerson |
| Abstract |
Osteoarthritis (OA) causes substantial pain and reduced health-related quality of life (HRQL). Although opioid analgesics are commonly used, the relative benefits of different opioids are poorly studied. Transdermal buprenorphine (TDB) offers an alternative to oral opioids for the treatment of moderate-to-severe chronic pain. This observational study of people with OA pain assessed satisfaction, HRQL and medication adherence. Patients in the UK with self-reported knee and/or hip OA who had been receiving one or more of TDB, co-codamol (an oral paracetamol/codeine combination) and tramadol for at least 1 month completed an online or telephone questionnaire. Medication satisfaction scores, HRQL scores (Short-Form 36 [SF-36]), medication adherence (Morisky Medication Adherence Scale [MMAS™]), adverse events and treatment discontinuations were recorded. Linear and logistic regression models were used to compare the treatment effect of TDB with co-codamol or tramadol. Overall, 966 patients met the inclusion criteria; 701 were taking only one of the target medications (TDB: 85; co-codamol: 373; tramadol: 243). The largest age group was 50-59 years and 76.0 % of patients were female. The TDB group was younger, with more male patients, therefore the statistical models were adjusted for age and sex. Medication satisfaction scores were significantly higher in the TDB group than the other two groups (TDB vs. co-codamol: 3.56, 95 % confidence interval [CI] 1.90-6.68, p < 0.0001; TDB vs. tramadol: 3.22, 95 % CI 1.67-6.20, p = 0.0005). Physical Component Summary scores for HRQL and mean adherence were also higher in the TDB group, while Mental Component Summary HRQL scores were similar across the three groups. Patients with knee and/or hip OA pain treated with TDB were more satisfied and more adherent with their medication, and reported higher Physical Component Summary HRQL scores than those treated with co-codamol or tramadol, although demographic differences were observed between groups. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| New Zealand | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 117 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 13 | 11% |
| Student > Master | 12 | 10% |
| Student > Bachelor | 12 | 10% |
| Student > Doctoral Student | 8 | 7% |
| Researcher | 8 | 7% |
| Other | 24 | 21% |
| Unknown | 40 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 27% |
| Nursing and Health Professions | 19 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 9% |
| Psychology | 5 | 4% |
| Agricultural and Biological Sciences | 4 | 3% |
| Other | 6 | 5% |
| Unknown | 41 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2016.
All research outputs
#20,343,772
of 25,870,142 outputs
Outputs from The Patient - Patient-Centered Outcomes Research
#463
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Outputs of similar age
#270,874
of 370,193 outputs
Outputs of similar age from The Patient - Patient-Centered Outcomes Research
#10
of 12 outputs
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