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BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk

Overview of attention for article published in Journal of Medical Genetics, August 2012
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Title
BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk
Published in
Journal of Medical Genetics, August 2012
DOI 10.1136/jmedgenet-2012-101037
Pubmed ID
Authors

Amanda B Spurdle, Phillip J Whiley, Bryony Thompson, Bingjian Feng, Sue Healey, Melissa A Brown, Christopher Pettigrew, kConFab, Christi J Van Asperen, Margreet G E M Ausems, Anna A Kattentidt-Mouravieva, Ans M W van den Ouweland, Dutch Belgium UV Consortium, Annika Lindblom, Maritta H Pigg, Rita K Schmutzler, Christoph Engel, Alfons Meindl, German Consortium of Hereditary Breast and Ovarian Cancer, Sandrine Caputo, Olga M Sinilnikova, Rosette Lidereau, French COVAR group collaborators, Fergus J Couch, Lucia Guidugli, Thomas van Overeem Hansen, Mads Thomassen, Diana M Eccles, Kathy Tucker, Javier Benitez, Susan M Domchek, Amanda E Toland, Elizabeth J Van Rensburg, Barbara Wappenschmidt, Åke Borg, Maaike P G Vreeswijk, David E Goldgar

Abstract

Clinical classification of rare sequence changes identified in the breast cancer susceptibility genes BRCA1 and BRCA2 is essential for appropriate genetic counselling of individuals carrying these variants. We previously showed that variant BRCA1 c.5096G>A p.Arg1699Gln in the BRCA1 transcriptional transactivation domain demonstrated equivocal results from a series of functional assays, and proposed that this variant may confer low to moderate risk of cancer.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Unknown 76 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 24%
Student > Ph. D. Student 11 14%
Student > Master 10 13%
Other 6 8%
Student > Bachelor 5 6%
Other 13 17%
Unknown 14 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 28%
Medicine and Dentistry 19 24%
Biochemistry, Genetics and Molecular Biology 16 21%
Unspecified 1 1%
Physics and Astronomy 1 1%
Other 4 5%
Unknown 15 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2017.
All research outputs
#17,662,702
of 22,673,450 outputs
Outputs from Journal of Medical Genetics
#2,700
of 2,912 outputs
Outputs of similar age
#124,110
of 167,577 outputs
Outputs of similar age from Journal of Medical Genetics
#19
of 21 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,912 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,577 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.