Title |
Diagnostic randomized controlled trials: the final frontier
|
---|---|
Published in |
Trials, August 2012
|
DOI | 10.1186/1745-6215-13-137 |
Pubmed ID | |
Authors |
Marc Rodger, Tim Ramsay, Dean Fergusson |
Abstract |
Clinicians, patients, governments, third-party payers, and the public take for granted that diagnostic tests are accurate, safe and effective. However, we may be seriously misled if we are relying on robust study design to ensure accurate, safe, and effective diagnostic tests. Properly conducted, randomized controlled trials are the gold standard for assessing the effectiveness and safety of interventions, yet are rarely conducted in the assessment of diagnostic tests. Instead, diagnostic cohort studies are commonly performed to assess the characteristics of a diagnostic test including sensitivity and specificity. While diagnostic cohort studies can inform us about the relative accuracy of an experimental diagnostic intervention compared to a reference standard, they do not inform us about whether the differences in accuracy are clinically important, or the degree of clinical importance (in other words, the impact on patient outcomes). In this commentary we provide the advantages of the diagnostic randomized controlled trial and suggest a greater awareness and uptake in their conduct. Doing so will better ensure that patients are offered diagnostic procedures that will make a clinical difference. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 26% |
Canada | 4 | 21% |
United States | 2 | 11% |
Netherlands | 1 | 5% |
Denmark | 1 | 5% |
Australia | 1 | 5% |
Mexico | 1 | 5% |
Unknown | 4 | 21% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 42% |
Practitioners (doctors, other healthcare professionals) | 6 | 32% |
Scientists | 5 | 26% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | <1% |
Australia | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Egypt | 1 | <1% |
United States | 1 | <1% |
Unknown | 116 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 20% |
Researcher | 24 | 20% |
Student > Master | 16 | 13% |
Other | 9 | 7% |
Professor | 8 | 7% |
Other | 23 | 19% |
Unknown | 18 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 53 | 43% |
Mathematics | 6 | 5% |
Biochemistry, Genetics and Molecular Biology | 5 | 4% |
Nursing and Health Professions | 4 | 3% |
Agricultural and Biological Sciences | 4 | 3% |
Other | 22 | 18% |
Unknown | 28 | 23% |