Title |
Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor
|
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Published in |
Nature Immunology, August 2012
|
DOI | 10.1038/ni.2394 |
Pubmed ID | |
Authors |
Carrie R Willcox, Vincent Pitard, Sonia Netzer, Lionel Couzi, Mahboob Salim, Tobias Silberzahn, Jean-François Moreau, Adrian C Hayday, Benjamin E Willcox, Julie Déchanet-Merville |
Abstract |
T cells bearing γδ T cell antigen receptors (TCRs) function in lymphoid stress surveillance. However, the contribution of γδ TCRs to such responses is unclear. Here we found that the TCR of a human V(γ)4V(δ)5 clone directly bound endothelial protein C receptor (EPCR), which allowed γδ T cells to recognize both endothelial cells targeted by cytomegalovirus and epithelial tumors. EPCR is a major histocompatibility complex-like molecule that binds lipids analogously to the antigen-presenting molecule CD1d. However, the V(γ)4V(δ)5 TCR bound EPCR independently of lipids, in an antibody-like way. Moreover, the recognition of target cells by γδ T cells required a multimolecular stress signature composed of EPCR and costimulatory ligand(s). Our results demonstrate how a γδ TCR mediates recognition of broadly stressed human cells by engaging a stress-regulated self antigen. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Switzerland | 1 | <1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
France | 1 | <1% |
Unknown | 210 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 50 | 23% |
Researcher | 36 | 17% |
Student > Bachelor | 26 | 12% |
Student > Master | 22 | 10% |
Student > Doctoral Student | 11 | 5% |
Other | 20 | 9% |
Unknown | 51 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 56 | 26% |
Immunology and Microbiology | 45 | 21% |
Biochemistry, Genetics and Molecular Biology | 28 | 13% |
Medicine and Dentistry | 24 | 11% |
Chemistry | 3 | 1% |
Other | 7 | 3% |
Unknown | 53 | 25% |