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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor
|
|---|---|
| Published in |
Nature Immunology, August 2012
|
| DOI | 10.1038/ni.2394 |
| Pubmed ID | |
| Authors |
Carrie R Willcox, Vincent Pitard, Sonia Netzer, Lionel Couzi, Mahboob Salim, Tobias Silberzahn, Jean-François Moreau, Adrian C Hayday, Benjamin E Willcox, Julie Déchanet-Merville |
| Abstract |
T cells bearing γδ T cell antigen receptors (TCRs) function in lymphoid stress surveillance. However, the contribution of γδ TCRs to such responses is unclear. Here we found that the TCR of a human V(γ)4V(δ)5 clone directly bound endothelial protein C receptor (EPCR), which allowed γδ T cells to recognize both endothelial cells targeted by cytomegalovirus and epithelial tumors. EPCR is a major histocompatibility complex-like molecule that binds lipids analogously to the antigen-presenting molecule CD1d. However, the V(γ)4V(δ)5 TCR bound EPCR independently of lipids, in an antibody-like way. Moreover, the recognition of target cells by γδ T cells required a multimolecular stress signature composed of EPCR and costimulatory ligand(s). Our results demonstrate how a γδ TCR mediates recognition of broadly stressed human cells by engaging a stress-regulated self antigen. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Switzerland | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Unknown | 210 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 50 | 23% |
| Researcher | 36 | 17% |
| Student > Bachelor | 26 | 12% |
| Student > Master | 22 | 10% |
| Student > Doctoral Student | 11 | 5% |
| Other | 20 | 9% |
| Unknown | 51 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 26% |
| Immunology and Microbiology | 45 | 21% |
| Biochemistry, Genetics and Molecular Biology | 28 | 13% |
| Medicine and Dentistry | 24 | 11% |
| Chemistry | 3 | 1% |
| Other | 7 | 3% |
| Unknown | 53 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#2,786,052
of 24,150,351 outputs
Outputs from Nature Immunology
#1,458
of 3,992 outputs
Outputs of similar age
#18,115
of 170,147 outputs
Outputs of similar age from Nature Immunology
#9
of 38 outputs
Altmetric has tracked 24,150,351 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,992 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.0. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,147 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.