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Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features

Overview of attention for article published in Pathology, June 2016
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Title
Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features
Published in
Pathology, June 2016
DOI 10.1016/j.pathol.2016.04.001
Pubmed ID
Authors

Amanda H. Seipel, Brett Delahunt, Hemamali Samaratunga, Lars Egevad

Abstract

Ductal adenocarcinoma of the prostate (DAC) is recognised as a subtype of prostatic adenocarcinoma, but its diagnostic criteria and biology remain controversial. DAC was first thought to stem from Müllerian duct remnants, but further studies suggest a prostatic origin. DAC is composed of tall, columnar, pseudostratified epithelium with a papillary, cribriform, glandular or solid architecture. The diagnosis is based on morphology alone with papillary architecture being the most helpful diagnostic feature. The tumour is rare in a pure form and most cases are combined with acinar adenocarcinoma. The most common differential diagnoses of DAC are intraductal carcinoma of the prostate and high-grade prostatic intraepithelial neoplasia. Patients often present at an advanced clinicopathological stage. High rates of extra-prostatic extension, seminal vesicle invasion, local and regional metastases, and positive surgical margins are seen after radical prostatectomy. DAC metastasises to sites that are less commonly seen for prostate cancer such as lung, brain, testis and penis. The morphology and the unusual metastatic locations make the accurate diagnosis of metastases challenging, but a positive immunostain for prostate specific markers may be helpful. The correct identification of DAC has implications for treatment as well as outcome.

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X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 50 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 14%
Student > Postgraduate 7 14%
Student > Ph. D. Student 6 12%
Student > Bachelor 4 8%
Student > Doctoral Student 3 6%
Other 12 24%
Unknown 12 24%
Readers by discipline Count As %
Medicine and Dentistry 27 53%
Biochemistry, Genetics and Molecular Biology 2 4%
Unspecified 1 2%
Arts and Humanities 1 2%
Physics and Astronomy 1 2%
Other 3 6%
Unknown 16 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2017.
All research outputs
#15,740,207
of 25,374,647 outputs
Outputs from Pathology
#666
of 1,528 outputs
Outputs of similar age
#201,814
of 353,558 outputs
Outputs of similar age from Pathology
#11
of 20 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,528 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,558 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.