| Title |
Transplantation of the Pancreas
|
|---|---|
| Published in |
Current Diabetes Reports, July 2012
|
| DOI | 10.1007/s11892-012-0293-4 |
| Pubmed ID | |
| Authors |
Ugo Boggi, Fabio Vistoli, Francesca Maria Egidi, Piero Marchetti, Nelide De Lio, Vittorio Perrone, Fabio Caniglia, Stefano Signori, Massimiliano Barsotti, Matteo Bernini, Margherita Occhipinti, Daniele Focosi, Gabriella Amorese |
| Abstract |
Pancreas transplantation consistently induces insulin-independence in beta-cell-penic diabetic patients, but at the cost of major surgery and life-long immunosuppression. One year after grafting, patient survival rate now exceeds 95 % across recipient categories, while insulin independence is maintained in some 85 % of simultaneous pancreas and kidney recipients and in nearly 80 % of solitary pancreas transplant recipients. The half-life of the pancreas graft currently averages 16.7 years, being the longest among extrarenal grafts, and substantially matching the one of renal grafts from deceased donors. The difference between expected (100 %) and actual insulin-independence rate is mostly explained by technical failure in the postoperative phase, and rejection in the long-term period. Death with a functioning graft remains a further major issue, especially in uremic patients who have undergone prolonged periods of dialysis. Refinements in graft preservation, surgical techniques, immunosuppression, and prophylactic treatments are expected to further improve the results of pancreas transplantation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 58 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 17% |
| Student > Bachelor | 6 | 10% |
| Other | 5 | 9% |
| Student > Postgraduate | 4 | 7% |
| Professor > Associate Professor | 4 | 7% |
| Other | 15 | 26% |
| Unknown | 14 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 45% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Social Sciences | 2 | 3% |
| Nursing and Health Professions | 2 | 3% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 18 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2012.
All research outputs
#18,313,878
of 22,675,759 outputs
Outputs from Current Diabetes Reports
#771
of 1,005 outputs
Outputs of similar age
#126,091
of 164,639 outputs
Outputs of similar age from Current Diabetes Reports
#17
of 23 outputs
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