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Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?

Overview of attention for article published in Glycoconjugate Journal, June 2016
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Title
Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?
Published in
Glycoconjugate Journal, June 2016
DOI 10.1007/s10719-016-9693-z
Pubmed ID
Authors

Aowen Zhuang, Josephine M. Forbes

Abstract

Diabetic patients are postulated to be in a perpetual state of oxidative stress and inflammation at sites where chronic complications occur. The accumulation of AGEs derived from both endogenous and exogenous sources (such as the diet) have been implicated in the development and progression of diabetic complications, particularly nephropathy. There has been some interest in investigating the potential for reducing the AGE burden in chronic disease, through the action of AGE "clearance" receptors, such as the advanced glycation end-product receptor 1 (AGE-R1). Reducing the burden of AGEs has been linked to attenuation of inflammation, slower progression of diabetic complications (in particular vascular and renal complications) and has been shown to extend lifespan. To date, however, there have been no direct investigations into whether AGE-R1 has any role in modulating normal kidney function, or specifically during the development and progression of diabetes. This mini-review will focus on the recent advances in knowledge around the mechanistic function of AGE-R1 and the implications of this for the pathogenesis of diabetic kidney disease.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 18%
Student > Bachelor 7 18%
Researcher 6 15%
Student > Master 4 10%
Professor > Associate Professor 2 5%
Other 5 13%
Unknown 9 23%
Readers by discipline Count As %
Medicine and Dentistry 11 28%
Biochemistry, Genetics and Molecular Biology 7 18%
Agricultural and Biological Sciences 5 13%
Psychology 2 5%
Sports and Recreations 2 5%
Other 4 10%
Unknown 9 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2016.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Glycoconjugate Journal
#800
of 929 outputs
Outputs of similar age
#271,843
of 355,635 outputs
Outputs of similar age from Glycoconjugate Journal
#22
of 35 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 929 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,635 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.