Title |
Targeting and transport: How microtubules control focal adhesion dynamics
|
---|---|
Published in |
Journal of Cell Biology, August 2012
|
DOI | 10.1083/jcb.201206050 |
Pubmed ID | |
Authors |
Samantha Stehbens, Torsten Wittmann |
Abstract |
Directional cell migration requires force generation that relies on the coordinated remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin-based focal adhesions (FAs). Normal FA turnover requires dynamic microtubules, and three members of the diverse group of microtubule plus-end-tracking proteins are principally involved in mediating microtubule interactions with FAs. Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling, and recent evidence suggests that microtubule-mediated clathrin-dependent and -independent endocytosis regulates FA dynamics. In addition, FA-associated microtubules may provide a polarized microtubule track for localized secretion of matrix metalloproteases (MMPs). Thus, different aspects of the molecular mechanisms by which microtubules control FA turnover in migrating cells are beginning to emerge. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 6 | 2% |
Japan | 3 | <1% |
Netherlands | 2 | <1% |
United States | 2 | <1% |
Brunei Darussalam | 1 | <1% |
Argentina | 1 | <1% |
Finland | 1 | <1% |
Spain | 1 | <1% |
Germany | 1 | <1% |
Other | 0 | 0% |
Unknown | 331 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 119 | 34% |
Researcher | 69 | 20% |
Student > Master | 30 | 9% |
Student > Bachelor | 26 | 7% |
Student > Doctoral Student | 18 | 5% |
Other | 44 | 13% |
Unknown | 43 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 158 | 45% |
Biochemistry, Genetics and Molecular Biology | 74 | 21% |
Medicine and Dentistry | 18 | 5% |
Engineering | 12 | 3% |
Physics and Astronomy | 8 | 2% |
Other | 25 | 7% |
Unknown | 54 | 15% |