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Targeting and transport: How microtubules control focal adhesion dynamics

Overview of attention for article published in Journal of Cell Biology, August 2012
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  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

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2 X users
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3 Facebook pages

Citations

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203 Dimensions

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349 Mendeley
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Title
Targeting and transport: How microtubules control focal adhesion dynamics
Published in
Journal of Cell Biology, August 2012
DOI 10.1083/jcb.201206050
Pubmed ID
Authors

Samantha Stehbens, Torsten Wittmann

Abstract

Directional cell migration requires force generation that relies on the coordinated remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin-based focal adhesions (FAs). Normal FA turnover requires dynamic microtubules, and three members of the diverse group of microtubule plus-end-tracking proteins are principally involved in mediating microtubule interactions with FAs. Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling, and recent evidence suggests that microtubule-mediated clathrin-dependent and -independent endocytosis regulates FA dynamics. In addition, FA-associated microtubules may provide a polarized microtubule track for localized secretion of matrix metalloproteases (MMPs). Thus, different aspects of the molecular mechanisms by which microtubules control FA turnover in migrating cells are beginning to emerge.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 349 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 6 2%
Japan 3 <1%
Netherlands 2 <1%
United States 2 <1%
Brunei Darussalam 1 <1%
Argentina 1 <1%
Finland 1 <1%
Spain 1 <1%
Germany 1 <1%
Other 0 0%
Unknown 331 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 119 34%
Researcher 69 20%
Student > Master 30 9%
Student > Bachelor 26 7%
Student > Doctoral Student 18 5%
Other 44 13%
Unknown 43 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 158 45%
Biochemistry, Genetics and Molecular Biology 74 21%
Medicine and Dentistry 18 5%
Engineering 12 3%
Physics and Astronomy 8 2%
Other 25 7%
Unknown 54 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2012.
All research outputs
#15,091,226
of 25,373,627 outputs
Outputs from Journal of Cell Biology
#10,235
of 11,939 outputs
Outputs of similar age
#108,809
of 186,113 outputs
Outputs of similar age from Journal of Cell Biology
#39
of 99 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,939 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,113 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.