Title |
Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups
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Published in |
Annals of the Rheumatic Diseases, August 2012
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DOI | 10.1136/annrheumdis-2012-201851 |
Pubmed ID | |
Authors |
Kenneth M Kaufman, Jian Zhao, Jennifer A Kelly, Travis Hughes, Adam Adler, Elena Sanchez, Joshua O Ojwang, Carl D Langefeld, Julie T Ziegler, Adrienne H Williams, Mary E Comeau, Miranda C Marion, Stuart B Glenn, Rita M Cantor, Jennifer M Grossman, Bevra H Hahn, Yeong Wook Song, Chack-Yung Yu, Judith A James, Joel M Guthridge, Elizabeth E Brown, Graciela S Alarcón, Robert P Kimberly, Jeffrey C Edberg, Rosalind Ramsey-Goldman, Michelle A Petri, John D Reveille, Luis M Vilá, Juan-Manuel Anaya, Susan A Boackle, Anne M Stevens, Barry I Freedman, Lindsey A Criswell, Bernardo A Pons-Estel on behalf of the Argentine Collaborative Group, Joo-Hyun Lee, Ji-Seon Lee, Deh-Ming Chang, R Hal A Scofield, Gary S Gilkeson, Joan T Merrill, Timothy B Niewold, Timothy James Vyse, Sang-Cheol Bae, Marta E Alarcón-Riquelme on behalf of the BIOLUPUS network, Chaim O Jacob, Kathy Moser Sivils, Patrick M Gaffney, John B Harley, Amr H Sawalha, Betty P Tsao |
Abstract |
The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the underlying causal variant(s) conferring risk of SLE. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 1% |
United States | 1 | 1% |
Colombia | 1 | 1% |
Netherlands | 1 | 1% |
Unknown | 76 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 18% |
Researcher | 11 | 14% |
Student > Master | 8 | 10% |
Student > Bachelor | 5 | 6% |
Professor | 4 | 5% |
Other | 13 | 16% |
Unknown | 25 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 24% |
Agricultural and Biological Sciences | 11 | 14% |
Biochemistry, Genetics and Molecular Biology | 9 | 11% |
Immunology and Microbiology | 8 | 10% |
Engineering | 4 | 5% |
Other | 4 | 5% |
Unknown | 25 | 31% |