Title |
Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement
|
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Published in |
PLOS Medicine, August 2012
|
DOI | 10.1371/journal.pmed.1001297 |
Pubmed ID | |
Authors |
Ilse C. E. Hendriksen, Juliet Mwanga-Amumpaire, Lorenz von Seidlein, George Mtove, Lisa J. White, Rasaq Olaosebikan, Sue J. Lee, Antoinette K. Tshefu, Charles Woodrow, Ben Amos, Corine Karema, Somporn Saiwaew, Kathryn Maitland, Ermelinda Gomes, Wirichada Pan-Ngum, Samwel Gesase, Kamolrat Silamut, Hugh Reyburn, Sarah Joseph, Kesinee Chotivanich, Caterina I. Fanello, Nicholas P. J. Day, Nicholas J. White, Arjen M. Dondorp |
Abstract |
In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by mature sequestered parasites and can be used to estimate the total parasite burden. We investigated the prognostic significance of plasma PfHRP2 and used it to estimate the malaria-attributable fraction in African children diagnosed with severe malaria. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 17% |
Canada | 2 | 17% |
Vietnam | 1 | 8% |
Switzerland | 1 | 8% |
United States | 1 | 8% |
Unknown | 5 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 42% |
Scientists | 4 | 33% |
Practitioners (doctors, other healthcare professionals) | 2 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Tanzania, United Republic of | 3 | 2% |
Ethiopia | 1 | <1% |
Kenya | 1 | <1% |
Canada | 1 | <1% |
Peru | 1 | <1% |
Denmark | 1 | <1% |
Rwanda | 1 | <1% |
United States | 1 | <1% |
Unknown | 171 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 20% |
Student > Master | 28 | 15% |
Researcher | 25 | 14% |
Student > Doctoral Student | 14 | 8% |
Student > Bachelor | 13 | 7% |
Other | 40 | 22% |
Unknown | 25 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 53 | 29% |
Agricultural and Biological Sciences | 24 | 13% |
Biochemistry, Genetics and Molecular Biology | 14 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
Nursing and Health Professions | 7 | 4% |
Other | 40 | 22% |
Unknown | 35 | 19% |