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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases
|
|---|---|
| Published in |
Neuroscience & Biobehavioral Reviews, June 2016
|
| DOI | 10.1016/j.neubiorev.2016.06.003 |
| Pubmed ID | |
| Authors |
Nils C. Gassen, George P. Chrousos, Elisabeth B. Binder, Anthony S. Zannas |
| Abstract |
Life stress has been associated with accelerated cellular aging and increased risk for developing aging-related diseases; however, the underlying molecular mechanisms remain elusive. A highly relevant process that may underlie this association is epigenetic regulation. In this review, we build upon existing evidence to propose a model whereby exposure to life stress, in part via its effects on the hypothalamic-pituitary axis and the glucocorticoid signaling system, may alter the epigenetic landscape across the lifespan and, consequently, influence genomic regulation and function in ways that are conducive to the development of aging-related diseases. This model is supported by recent studies showing that life stressors and stress-related phenotypes can accelerate epigenetic aging, a measure that is based on DNA methylation prediction of chronological age and has been associated with several aging-related disease phenotypes. We discuss the implications of this model for the prevention and treatment of aging-related diseases, as well as the challenges and limitations of this line of research. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 152 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 18% |
| Student > Master | 23 | 15% |
| Researcher | 22 | 14% |
| Student > Bachelor | 17 | 11% |
| Student > Doctoral Student | 10 | 6% |
| Other | 27 | 17% |
| Unknown | 28 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 26 | 17% |
| Medicine and Dentistry | 23 | 15% |
| Agricultural and Biological Sciences | 19 | 12% |
| Biochemistry, Genetics and Molecular Biology | 13 | 8% |
| Neuroscience | 11 | 7% |
| Other | 23 | 15% |
| Unknown | 40 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2016.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Neuroscience & Biobehavioral Reviews
#3,588
of 4,284 outputs
Outputs of similar age
#237,980
of 368,661 outputs
Outputs of similar age from Neuroscience & Biobehavioral Reviews
#97
of 126 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,284 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.4. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,661 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.