| Title |
A Randomized Controlled Trial to Prevent Depression and Ameliorate Insulin Resistance in Adolescent Girls at Risk for Type 2 Diabetes
|
|---|---|
| Published in |
Annals of Behavioral Medicine, June 2016
|
| DOI | 10.1007/s12160-016-9801-0 |
| Pubmed ID | |
| Authors |
Lauren B. Shomaker, Nichole R. Kelly, Courtney K. Pickworth, Omni L. Cassidy, Rachel M. Radin, Lisa M. Shank, Anna Vannucci, Katherine A. Thompson, Sara A. Armaiz-Flores, Sheila M. Brady, Andrew P. Demidowich, Ovidiu A. Galescu, Amber B. Courville, Cara Olsen, Kong Y. Chen, Eric Stice, Marian Tanofsky-Kraff, Jack A. Yanovski |
| Abstract |
Prospective data suggest depressive symptoms worsen insulin resistance and accelerate type 2 diabetes (T2D) onset. We sought to determine whether reducing depressive symptoms in overweight/obese adolescents at risk for T2D would increase insulin sensitivity and mitigate T2D risk. We conducted a parallel-group, randomized controlled trial comparing a 6-week cognitive-behavioral (CB) depression prevention group with a 6-week health education (HE) control group in 119 overweight/obese adolescent girls with mild-to-moderate depressive symptoms (Center for Epidemiological Studies-Depression Scale [CES-D] ≥16) and T2D family history. Primary outcomes were baseline to post-intervention changes in CES-D and whole body insulin sensitivity index (WBISI), derived from 2-h oral glucose tolerance tests. Outcome changes were compared between groups using ANCOVA, adjusting for respective baseline outcome, puberty, race, facilitator, T2D family history degree, baseline age, adiposity, and adiposity change. Multiple imputation was used for missing data. Depressive symptoms decreased (p < 0.001) in CB and HE from baseline to posttreatment, but did not differ between groups (ΔCESD = -12 vs. -11, 95 % CI difference = -4 to +1, p = 0.31). Insulin sensitivity was stable (p > 0.29) in CB and HE (ΔWBISI = 0.1 vs. 0.2, 95 % CI difference = -0.6 to +0.4, p = 0.63). Among all participants, reductions in depressive symptoms were associated with improvements in insulin sensitivity (p = 0.02). Girls at risk for T2D displayed reduced depressive symptoms following 6 weeks of CB or HE. Decreases in depressive symptoms related to improvements in insulin sensitivity. Longer-term follow-up is needed to determine whether either program causes sustained decreases in depressive symptoms and improvements in insulin sensitivity. The trial was registered with clinicaltrials.gov (NCT01425905). |
Mendeley readers
The data shown below were compiled from readership statistics for 222 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 222 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 30 | 14% |
| Student > Bachelor | 30 | 14% |
| Researcher | 24 | 11% |
| Student > Ph. D. Student | 19 | 9% |
| Student > Doctoral Student | 14 | 6% |
| Other | 32 | 14% |
| Unknown | 73 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 40 | 18% |
| Medicine and Dentistry | 32 | 14% |
| Nursing and Health Professions | 25 | 11% |
| Social Sciences | 9 | 4% |
| Biochemistry, Genetics and Molecular Biology | 8 | 4% |
| Other | 22 | 10% |
| Unknown | 86 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2016.
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#20,334,427
of 22,879,161 outputs
Outputs from Annals of Behavioral Medicine
#1,338
of 1,390 outputs
Outputs of similar age
#305,295
of 352,770 outputs
Outputs of similar age from Annals of Behavioral Medicine
#19
of 20 outputs
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