| Title |
Activation of transcription factors by extracellular nucleotides in immune and related cell types
|
|---|---|
| Published in |
Purinergic Signalling, January 2007
|
| DOI | 10.1007/s11302-006-9037-8 |
| Pubmed ID | |
| Authors |
Souzan Armstrong, Jasminka Korcok, Stephen M. Sims, S. Jeffrey Dixon |
| Abstract |
Extracellular nucleotides, acting through P2 receptors, can regulate gene expression via intracellular signaling pathways that control the activity of transcription factors. Relatively little is known about the activation of transcription factors by nucleotides in immune cells. The NF-kappaB family of transcription factors is critical for many immune and inflammatory responses. Nucleotides released from damaged or stressed cells can act alone through certain P2 receptors to alter NF-kappaB activity or they can enhance responses induced by pathogen-associated molecules such as LPS. Nucleotides have also been shown to regulate the activity of other transcription factors (AP-1, NFAT, CREB and STAT) in immune and related cell types. Here, we provide an overview of transcription factors shown to be activated by nucleotides in immune cells, and describe what is known about their mechanisms of activation and potential functions. Furthermore, we propose areas for future work in this new and expanding field. |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Portugal | 1 | 3% |
| Russia | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 28 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 7 | 22% |
| Student > Master | 5 | 16% |
| Student > Ph. D. Student | 3 | 9% |
| Professor | 2 | 6% |
| Researcher | 2 | 6% |
| Other | 5 | 16% |
| Unknown | 8 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 25% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Medicine and Dentistry | 3 | 9% |
| Neuroscience | 3 | 9% |
| Immunology and Microbiology | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 11 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2012.
All research outputs
#20,165,369
of 22,675,759 outputs
Outputs from Purinergic Signalling
#288
of 373 outputs
Outputs of similar age
#152,432
of 156,793 outputs
Outputs of similar age from Purinergic Signalling
#6
of 7 outputs
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So far Altmetric has tracked 373 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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