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Progression in smoldering Waldenström macroglobulinemia: long-term results

Overview of attention for article published in Blood, March 2012
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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Title
Progression in smoldering Waldenström macroglobulinemia: long-term results
Published in
Blood, March 2012
DOI 10.1182/blood-2011-10-384768
Pubmed ID
Authors

Robert A. Kyle, Joanne T. Benson, Dirk R. Larson, Terry M. Therneau, Angela Dispenzieri, Shaji Kumar, L. Joseph Melton, S. Vincent Rajkumar

Abstract

The purpose of this study was to define the risk of progression and survival of patients with smoldering Waldenström macroglobulinemia (SWM). SWM is defined clinically as having a serum monoclonal IgM protein≥3 g/dL and/or≥10% bone marrow lymphoplasmacytic infiltration but no evidence of end-organ damage (anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, or hepatosplenomegaly). We searched a computerized database and reviewed the medical records of all patients at Mayo Clinic who fulfilled the criteria of SWM between 1974 and 1995. During 285 cumulative person-years of follow-up of the 48 patients with SWM (median, 15.4 years), 34 (71%) progressed to symptomatic Waldenström macroglobulinemia (WM) requiring treatment, one to primary amyloidosis, and one to lymphoma (total, 75%). The cumulative probability of progression to symptomatic WM, amyloidosis, or lymphoma was 6% at 1 year, 39% at 3 years, 59% at 5 years, and 68% at 10 years. The major risk factors for progression were percentage of lymphoplasmacytic cells in the bone marrow, size of the serum M-spike, and the hemoglobin value. Patients with SWM should be followed and not treated until symptomatic WM develops. Treatment on a clinical trial for those at greatest risk of progression should be considered.

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X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 2 2%
Spain 1 1%
Brazil 1 1%
Unknown 83 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 14%
Other 11 13%
Researcher 10 11%
Student > Master 9 10%
Student > Postgraduate 8 9%
Other 18 21%
Unknown 19 22%
Readers by discipline Count As %
Medicine and Dentistry 50 57%
Biochemistry, Genetics and Molecular Biology 5 6%
Agricultural and Biological Sciences 4 5%
Linguistics 1 1%
Immunology and Microbiology 1 1%
Other 3 3%
Unknown 23 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2018.
All research outputs
#4,823,623
of 25,371,288 outputs
Outputs from Blood
#7,018
of 33,239 outputs
Outputs of similar age
#30,325
of 172,496 outputs
Outputs of similar age from Blood
#71
of 325 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,239 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,496 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 325 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.