| Title |
Adverse Effects of Long-Term Proton Pump Inhibitor Therapy
|
|---|---|
| Published in |
Digestive Diseases and Sciences, March 2011
|
| DOI | 10.1007/s10620-010-1560-3 |
| Pubmed ID | |
| Authors |
Edward Sheen, George Triadafilopoulos |
| Abstract |
Proton pump inhibitors have an excellent safety profile and have become one of the most commonly prescribed class of drugs in primary and specialty care. Long-term, sometimes lifetime, use is becoming increasingly common, often without appropriate indications. This paper is a detailed review of the current evidence on this important topic, focusing on the potential adverse effects of long-term proton pump inhibitor use that have generated the greatest concern: B12 deficiency; iron deficiency; hypomagnesemia; increased susceptibility to pneumonia, enteric infections, and fractures; hypergastrinemia and cancer; drug interactions; and birth defects. We explain the pathophysiological mechanisms that may underlie each of these relationships, review the existing evidence, and discuss implications for clinical management. The benefits of proton pump inhibitor use outweigh its risks in most patients. Elderly, malnourished, immune-compromised, chronically ill, and osteoporotic patients theoretically could be at increased risk from long-term therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 280 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 1% |
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Austria | 1 | <1% |
| United Kingdom | 1 | <1% |
| Israel | 1 | <1% |
| Unknown | 272 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 61 | 22% |
| Student > Master | 46 | 16% |
| Researcher | 30 | 11% |
| Student > Ph. D. Student | 25 | 9% |
| Student > Postgraduate | 20 | 7% |
| Other | 51 | 18% |
| Unknown | 47 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 123 | 44% |
| Pharmacology, Toxicology and Pharmaceutical Science | 25 | 9% |
| Agricultural and Biological Sciences | 23 | 8% |
| Nursing and Health Professions | 17 | 6% |
| Biochemistry, Genetics and Molecular Biology | 14 | 5% |
| Other | 20 | 7% |
| Unknown | 58 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2023.
All research outputs
#3,330,480
of 23,854,458 outputs
Outputs from Digestive Diseases and Sciences
#408
of 4,304 outputs
Outputs of similar age
#14,928
of 111,154 outputs
Outputs of similar age from Digestive Diseases and Sciences
#4
of 22 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,304 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,154 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.