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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE
|
|---|---|
| Published in |
The Journal of Experimental Medicine, September 2020
|
| DOI | 10.1084/jem.20200474 |
| Pubmed ID | |
| Authors |
Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, Xiaoguang Li, LuLin Jiang, Andrew P. Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E. Tanzi, Timothy Y. Huang, Huaxi Xu |
| Abstract |
Variations in many genes linked to sporadic Alzheimer's disease (AD) show abundant expression in microglia, but relationships among these genes remain largely elusive. Here, we establish isogenic human ESC-derived microglia-like cell lines (hMGLs) harboring AD variants in CD33, INPP5D, SORL1, and TREM2 loci and curate a comprehensive atlas comprising ATAC-seq, ChIP-seq, RNA-seq, and proteomics datasets. AD-like expression signatures are observed in AD mutant SORL1 and TREM2 hMGLs, while integrative multi-omic analysis of combined epigenetic and expression datasets indicates up-regulation of APOE as a convergent pathogenic node. We also observe cross-regulatory relationships between SORL1 and TREM2, in which SORL1R744X hMGLs induce TREM2 expression to enhance APOE expression. AD-associated SORL1 and TREM2 mutations also impaired hMGL Aβ uptake in an APOE-dependent manner in vitro and attenuated Aβ uptake/clearance in mouse AD brain xenotransplants. Using this modeling and analysis platform for human microglia, we provide new insight into epistatic interactions in AD genes and demonstrate convergence of microglial AD genes at the APOE locus. |
X Demographics
The data shown below were collected from the profiles of 54 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 33% |
| United Kingdom | 6 | 11% |
| India | 2 | 4% |
| Finland | 2 | 4% |
| France | 2 | 4% |
| Poland | 1 | 2% |
| Netherlands | 1 | 2% |
| Colombia | 1 | 2% |
| Chile | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 19 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 31 | 57% |
| Scientists | 18 | 33% |
| Science communicators (journalists, bloggers, editors) | 3 | 6% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 112 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 27% |
| Student > Ph. D. Student | 15 | 13% |
| Student > Bachelor | 9 | 8% |
| Other | 5 | 4% |
| Student > Master | 5 | 4% |
| Other | 10 | 9% |
| Unknown | 38 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 29 | 26% |
| Biochemistry, Genetics and Molecular Biology | 18 | 16% |
| Agricultural and Biological Sciences | 10 | 9% |
| Medicine and Dentistry | 7 | 6% |
| Immunology and Microbiology | 3 | 3% |
| Other | 5 | 4% |
| Unknown | 40 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2022.
All research outputs
#1,327,162
of 25,537,395 outputs
Outputs from The Journal of Experimental Medicine
#782
of 11,627 outputs
Outputs of similar age
#36,432
of 429,794 outputs
Outputs of similar age from The Journal of Experimental Medicine
#22
of 83 outputs
Altmetric has tracked 25,537,395 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,627 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 429,794 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.