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Mendeley readers
Attention Score in Context
| Title |
Association of PICALM with Cognitive Impairment in Parkinson's Disease
|
|---|---|
| Published in |
Movement Disorders, September 2020
|
| DOI | 10.1002/mds.28283 |
| Pubmed ID | |
| Authors |
María Teresa Periñán, Daniel Macías‐García, Miguel Ángel Labrador‐Espinosa, Silvia Jesús, Dolores Buiza‐Rueda, Astrid D. Adarmes‐Gómez, Laura Muñoz‐Delgado, Pilar Gómez‐Garre, Pablo Mir |
| Abstract |
Cognitive impairment is one of the most disabling nonmotor symptoms in Parkinson's disease (PD). Recently, a genome-wide association study in Alzheimer's disease has identified the PICALM rs3851179 polymorphism as one of the most significant susceptibility genes for Alzheimer's disease after APOE. The aim of this study was to determine the potential role of PICALM and its genetic interaction with APOE in the development of cognitive decline in PD. A discovery cohort of 712 patients with PD were genotyped for PICALM (rs3851179) and APOE (rs429358 and rs7412) polymorphisms. The association of PICALM and APOE-PICALM genetic interaction with cognitive dysfunction in PD was studied using logistic regression models, and the relationship of PICALM with cognitive decline onset was assessed with Cox regression analysis. PICALM effect was then replicated in an international, independent cohort (Parkinson's Progression Markers Initiative, N = 231). PICALM rs3851179 TT genotype was significantly associated with a decreased risk of cognitive impairment in PD (TT vs. CC + CT, P = 0.041, odds ratio = 0.309). Replication studies further demonstrated its protective effect on cognitive impairment in PD. In addition, the protective effect of the PICALM rs3851179 TT genotype was more pronounced in the APOE ε4 (-) carriers from the discovery cohort (P = 0.037, odds ratio = 0.241), although these results were not replicated in the Parkinson's Progression Markers Initiative cohort. Our results support the fact that PICALM is associated with cognitive impairment in PD. The understanding of its contribution to cognitive decline in PD could provide new targets for the development of novel therapies. © 2020 International Parkinson and Movement Disorder Society. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 19% |
| Student > Ph. D. Student | 3 | 12% |
| Student > Bachelor | 3 | 12% |
| Other | 1 | 4% |
| Lecturer | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 11 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 4 | 15% |
| Medicine and Dentistry | 3 | 12% |
| Computer Science | 2 | 8% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Business, Management and Accounting | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 11 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2022.
All research outputs
#2,051,383
of 23,237,082 outputs
Outputs from Movement Disorders
#665
of 4,742 outputs
Outputs of similar age
#56,330
of 401,005 outputs
Outputs of similar age from Movement Disorders
#64
of 136 outputs
Altmetric has tracked 23,237,082 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,742 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 401,005 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.